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The influence of ROS1 fusion partners and resistance mechanisms in ROS1-TKI-treated non-small cell lung cancer patients

Zwierenga, Fenneke; Dijkhuizen, Christa (Biomolecules & Health); Korthuis, Patrick; Timens, Wim; Groen, Harry; Hiltermann, Jeroen; van den Berg, Anke; Drayer, Lyndsay; van der Wekken, Anthonie

Clinical outcomes in ROS1-fusion positive (ROS1+) non-small cell lung cancer (NSCLC) by fusion partner and resistance mechanisms are limited. This cohort study included 56 ROS1+ patients (FISH or NGS confirmed); fusion partners were identified in 27 cases, including CD74 (n = 10), EZR (n = 7), and SDC4 …

2025-08-29GezondheidArtikel

Multilayered Tissue Assemblies Through Tuneable Biodegradable Polyhydroxyalkanoate Polymer (Mesh)-Reinforced Organ-Derived Extracellular Matrix Hydrogels

Getova, Vasilena E.; Pascual, Alex; Dijkstra, Rene; Gładysz, Magdalena Z.; Ubels, Didi; Wlodarczyk-Biegun, Malgorzata K.; Burgess, Janette K.; Siebring, Jeroen (Bioconversion And Fermentation Technology); Harmsen, Martin C.

Multi-layer cell constructs produced in vitro are an innovative treatment option to support the growing demand for therapy in regenerative medicine. Our research introduces a novel construct integrating organ-derived decellularised extracellular matrix (dECM) hydrogels and 3D-printed biodegradable polymer …

2025-07-11Techniek; …Artikel

ROS1+ in vitro models

Dijkhuizen, Christa (Biomolecules & Health); Korthuis, Patrick; Aguado, Cristina; Garcia-Román, Silvia; Aguilar-Hernández, Andrés; Drayer, Lyndsay; Hiltermann, Jeroen; De Looff, Margot (Biomolecules & Health); Milder, Fin (Biomolecules & Health); van den Berg, Anke; van der Wekken, Anthonie

2025-06-17GezondheidConferentiebijdrage

Assessment of two new ROS1+ NSCLC patient-derived cell lines as in vitro models for TKI resistance studies

Dijkhuizen, Christa (Biomolecules & Health); Korthuis, Patrick; Aguado, Cristina; Garcia-Román, Silvia; Aguilar-Hernández, Andrés; Drayer, Lyndsay; De Looff, Margot (Biomolecules & Health); Milder, Fin (Biomolecules & Health); van der Wekken, Anthonie; van den Berg, Anke

2025-06-13GezondheidConferentiebijdrage

Structural Aspects of the ROS1 Kinase Domain and Oncogenic Mutations

Vilachã, Juliana F.; Wassenaar, Tsjerk A.; Marrink, Siewert J.

Protein kinases function as pivotal regulators in biological events, governing essential cellular processes through the transfer of phosphate groups from ATP molecules to substrates. Dysregulation of kinase activity is frequently associated with cancer, ocasionally arising from chromosomal translocation …

2024-01-23AlgemeenAndersoortig materiaal

Meme Mikrodalgası Hipertermi Aplikatörü İçin Geliştirilen Doku Taklidi Jel Karakterizasyonuc (Tissue Mimicking Gel Characterization Developed for a Breast Microwave Hyperthermia Applicator)

Ömer Işık (Onderzoeker); Erdal Korkmaz (Onderzoeker)

İnsan vücudu ile elektromanyetik dalgaların etkileşimi, dokuların ve hücrelerin dielektrik özellikleri gibi faktörlerin yanı sıra diğer etkenler tarafından da şekillenir. Mikrodalga hipertermi ve mikrodalga görüntüleme uygulamalarında, deney ortamı ölçüm düzeneklerinde simülasyon sonuçlarını doğrulamak …

2023-10-30TechniekArtikel

Evidence for effect of l-serine, a novel therapy for GRIN2B-related neurodevelopmental disorder.

B. den Hollander; A.R.J. Veenvliet; Marieke Lindenschot; P. van Essen; G. Peters; A. Santos-Gómez; M. Olivella; X. Altafaj; M.M. Brands; B.A.W. Jacobs; C.D. van Karnebeek

RATIONALE: To date, causal therapy is potentially available for GRIN2B-related neurodevelopmental disorder (NDD) due to loss-of-function (LoF) variants in GRIN2B, resulting in dysfunction of the GluN2B subunit-containing N-methyl-d-aspartate receptor (NMDAR). Recently, in vitro experiments showed that …

2023AlgemeenArtikel

Optimization of an adverse outcome pathway network on chemical-induced cholestasis using an artificial intelligence-assisted data collection and confidence level quantification approach

Jonas van Ertvelde (Onderzoeker); Anouk Verhoeven (Onderzoeker); Amy Maerten (Onderzoeker); Axelle Cooreman (Onderzoeker); Bruna dos Santos Rodrigues (Onderzoeker); Julen Sanz-Serrano (Onderzoeker); Milos Mihajlovic (Onderzoeker); Ignacio Tripodi (Onderzoeker); Marc Teunis (Onderzoeker); Ramiro Jover (Onderzoeker); Thomas Luechtefeld (Onderzoeker); Tamara Vanhaecke (Onderzoeker); Jian Jang (Onderzoeker); Mathieu Vinken (Onderzoeker)

Background: Adverse outcome pathway (AOP) networks are versatile tools in toxicology and risk assessment that capture and visualize mechanisms driving toxicity originating from various data sources. They share a common structure consisting of a set of molecular initiating events and key events, connected …

2023GezondheidArtikel

In vitro–in silico-based prediction of inter-individual and inter-ethnic variations in the dose-dependent cardiotoxicity of R- and S-methadone in humans

Shi, M.; Dong, Y.; Bouwmeester, H.; Rietjens, I.M.C.M.; Strikwold, M. (Lector)

New approach methodologies predicting human cardiotoxicity are of interest to support or even replace in vivo-based drug safety testing. The present study presents an in vitro–in silico approach to predict the effect of inter-individual and inter-ethnic kinetic variations in the cardiotoxicity of R- …

2022-05-23GezondheidArtikel

Essentiële oliën

Nederlof, M.; Weerman, E.J. (Docent); Haenen, O.L.M. (Lector); Vrij, M.M.P.

De toenemende bacterieresistentie tegen antibiotica bij de mens èn in de aquacultuur vraagt om alternatieven. Op de HAS Hogeschool is, in samenwerking met de Wageningen Universiteit en NGN Products, via in vitro studies getest of essentiële oliën een remmend effect hebben op de groei van twee veelvoorkomende …

2021Natuur & LandbouwArtikel

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