We present the first genome sequence for a strain of the main mycetoma causative agent, Madurella mycetomatis. This 36.7-Mb genome sequence will offer new insights into the pathogenesis of mycetoma, and it will contribute to the development of better therapies for this neglected tropical disease.

Numerous databases containing information about DNA, RNA, and protein variations are available. Gene‐specific variant databases (locus‐specific variation databases, LSDBs) are typically curated and maintained for single genes or groups of genes for a certain disease(s). These databases are widely considered …

Background: To date, women are most often diagnosed with bacterial vaginosis (BV) using microscopy based Nugent scoring or Amsel criteria. However, the accuracy is less than optimal. The aim of the present study was to confirm the identity of known BV-associated composition profiles and evaluate indicators …

Extraintestinal pathogenic Escherichia coli sequence type 131 (ST131), typically fluoroquinolone-resistant (FQ-R) and/or extended-spectrum β-lactamase (ESBL)-producing, has emerged globally. Among clinical isolates, ST131, primarily its H30-R and H30-Rx subclones, accounts for most antimicrobial-resistant …

Zoekmachines worden persoonlijke assistenten bij het vinden van informatie: de robotisering van informatiemanagement, concludeert Hans Henseler. Die robotisering beperkt zich niet tot slimme persoonlijke assistenten. Er zullen ook chatbots verschijnen die met mensen communiceren. En autonome systemen …

The consistent and unambiguous description of sequence variants is essential to report and exchange information on the analysis of a genome. In particular, DNA diagnostics critically depends on accurate and standardized description and sharing of the variants detected. The sequence variant nomenclature …

Het laboratorium van de ziekenhuisapotheek van het OLVG bepaalt de concentratie van 13 antidepressiva in serum met behulp van de techniek LC-MS2. Alle antidepressiva worden nu met verschillende analysemethode geanalyseerd. Het laboratorium wil graag één uniforme multicomponent analysemethode voor het …

There is now a convergence of two modes of genetic testing, that of testing a few candidate genes at a time based on suspicion of a specific genetic disease, and that of genomic testing, especially when a candidate gene(s) is not suspected or known. Both aim to interpret pathogenicity of identified genetic …

Objectives: A large portion of anogenital cancers is caused by high-risk human papillomavirus (hrHPV) infections, which are especially common in HIV-infected men. We aimed to compare the incidence and clearance of anal and penile hrHPV infection between HIV-infected and HIV-negative MSM. Design: Analyses …

In May 23-29 2016, my colleague Dr. Gerard Parlevliet and myself, Prof. Dr. Willem van Leeuwen, were invited by the Tehran University of Medical Sciences to share information about microbiology and prevention of infections by performing workshops.