To study the ways in which compounds can induce adverse effects, toxicologists have been constructing Adverse Outcome Pathways (AOPs). An AOP can be considered as a pragmatic tool to capture and visualize mechanisms underlying different types of toxicity inflicted by any kind of stressor, and describes …

Wynand Alkema vertelt over het gebruik van ChatGPT in het ontwikkelen van nieuwe medicijnen. Een samenvatting van het praatje is hieronder weergegeven:The FAIR use of Large Language Models in the drug development pipeline.With the emergence of applications that are based on large language models (LLMs), …

The effects of stress may be alleviated when its impact or a decreased stress-resilience are detected early. This study explores whether wearable-measured sleep and resting HRV in police officers can be predicted by stress-related Ecological Momentary Assessment (EMA) measures in preceding days and predict …

Swales are widely used Sustainable Urban Drainage Systems (SuDS) that can reduce peak flow, collect and retain water and improve groundwater recharge. Most previous research has focused on the unsaturated infiltration rates of swales without considering the variation in infiltration rates under extreme …

Adverse Outcome Pathways (AOPs) are conceptual frameworks that tie an initial perturbation (molecular initiat- ing event) to a phenotypic toxicological manifestation (adverse outcome), through a series of steps (key events). They provide therefore a standardized way to map and organize toxicological …

The rapid implementation of large scale floating solar panels has consequences to water quality and local ecosystems. Environmental impacts depend on the dimensions, design and proportions of the system in relation to the size of the surface water, as well as the characteristics of the water system (currents, …

As a consequence of climate change and urbanization, many cities will have to deal with more flooding and extreme heat stress. This paper presents a framework to maximize the effectiveness of Nature-Based Solutions (NBS) for flood risk reduction and thermal comfort enhancement. The framework involves …

As a consequence of climate change and urbanization, many cities will have to deal with more flooding and extreme heat stress. This paper presents a framework to maximize the effectiveness of Nature-Based Solutions (NBS) for flood risk reduction and thermal comfort enhancement. The framework involves …

This research used a newly developed, full-scale infiltration testing (FSIT) procedure to determine the saturated surface infiltration rate of 16 existing permeable pavement installations in the Netherlands that have been in service for a number of years. Newly installed permeable pavements in the Netherlands …

Abstract 1 Scope A major downside of oral immunotherapy (OIT) for food allergy is the risk of severe side effects. Non‐digestible short‐ and long‐chain fructo‐oligosaccharides (scFOS/lcFOS) reduce allergy development in murine models. Therefore, it is hypothesized that scFOS/lcFOS can also support …