Sepsis is a life-threatening organ dysfunction caused by a dysregulated immune response to infection. It is the number one cause of death in the Intensive Care Unit (ICU), accounting for 6 million casualties every year. Unfortunately, all clinical trials in the last decade failed due to the highly complex …

Alzheimer's disease (AD) is the common neurodegenerative disorder and the most frequent cause of dementia. The disease accounts around 80% of all dementia diagnoses. The main reason of developing AD is amyloid cascade which starts from missense mutations in APP (amyloid precursor protein), Rho-associated …

Despite tremendous efforts, the exact structure of SARS-CoV-2 and related betacoronaviruses remains elusive. SARS-CoV-2 envelope is a key structural component of the virion that encapsulates viral RNA. It is composed of three structural proteins, spike, membrane (M), and envelope, which interact with …

Background: Lung fibroblasts are implicated in abnormal tissue repair in chronic obstructive pulmonary disease (COPD). The exact mechanisms are unknown and comprehensive analysis comparing COPD- and control fibroblasts is lacking. Aim: To gain insight in the role of lung fibroblasts in COPD pathology …

Standard SARS-CoV-2 testing protocols using nasopharyngeal/throat (NP/T) swabs are invasive and require trained medical staff for reliable sampling. In addition, it has been shown that PCR is more sensitive as compared to antigen-based tests. Here we describe the analytical and clinical evaluation of …

This literature review will focus on how CRISPR/Cas can be used in curing diabetes. CRISPR is a newly discovered genetical engineering tool that was first found in bacteria and it has an important immune function, protecting them from viral infections by cutting the viral DNA, thereby disabling it. Researchers …

The coronavirus disease-19 (COVID-19) pandemic still poses serious threats to global public health. Therefore, the scientific community is desperately looking for suitable vaccines and pharmacological treatment options. This thesis completes the internship at Specs Compound Handling BV and describes …

Het doel van deze studie is niet alleen om het model van de XRN1 stalling site voor MODV te verifiëren, maar ook om vast stellen in hoeverre er variaties zijn in de structuur van de XRN1 stalling sites binnen het genus flavivirussen.

The main objective of this study is to reveal the heterogeneity of cell types hidden in the developed brain organoids. A secondary goal is to discover gene expression differences among these identified cell types between the cells with 22q11.2 DS and healthy controls. The latter is done to get a better …

Klotho knock-out mice are an important model for vascular calcification, which is associated with chronic kidney disease. In chronic kidney disease, serum magnesium inversely correlates with vascular calcification. Here we determine the effects of serum magnesium on aortic calcification in Klotho knock-out …