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ALACEN: A Holistic Herbaceous Biomass Fractionation Process Attaining a Xylose-Rich Stream for Direct Microbial Conversion to Bioplastics

Bertran Llorens, Salvador; Zhou, Wen; A. Palazzolo, Martin; Colpa, Dana; Euverink, Gert Jan Willem; Krooneman, Janneke (Bioconversion And Fermentation Technology); Deuss, Peter

Lignocellulose biorefining is a promising technologyfor the sustainable production of chemicals and biopolymers.Usually, when one component is focused on, the chemical natureand yield of the others are compromised. Thus, one of thebottlenecks in biomass biorefining is harnessing the maximumvalue from …

2024-05-08AlgemeenArtikel

A multidisciplinary lifestyle program for metabolic syndrome-associated osteoarthritis

Walrabenstein, Wendy; Wagenaar, Carlijn A.; van de Put, Marieke; van der Leeden, Marike; Gerritsen, Martijn; Twisk, Jos W.R.; van der Esch, Martin (Lectoraat Interdisciplinaire Zorg Voor Chronische Gewrichtsaandoeningen); van Middendorp, Henriët; Weijs, Peter J.M. (Lectoraat Voeding En Beweging); Roorda, Leo D.; van Schaardenburg, Dirkjan

Objective To determine the effectiveness of the “Plants for Joints” multidisciplinary lifestyle program in patients with metabolic syndrome-associated osteoarthritis (MSOA). Design Patients with hip or knee MSOA were randomized to the intervention or control group. The intervention group followed a 16-week …

2023-11AlgemeenArtikel

Conversion of a Xylose-rich Stream from Biomass-biorefining into Polyhydroxyalkanoate (PHA) by Schlegelella thermodepolymerans

Krooneman, Janneke (Bioconversion And Fermentation Technology); Bertran Llorens, Salvador; Zhou, Wen; Palazzolo, Martin A.; Colpa, Dana; Euverink, Gerrit Jan Willem; Deuss, Peter

The transition to a biobased economy necessitates utilizing renewable resources as a sustainable alternative to traditional fossil fuels. Bioconversion is a way to produce many green chemicals from renewables, e.g., biopolymers like PHAs. However, fermentation and bioconversion processes mostly rely …

2023-09-13AlgemeenConferentiebijdrage

A multidisciplinary lifestyle program for rheumatoid arthritis: the 'Plants for Joints' randomized controlled trial

Walrabenstein, Wendy; Wagenaar, Carlijn A; van der Leeden, Marike; Turkstra, Franktien; Twisk, Jos W R; Boers, Maarten; van Middendorp, Henriët; Weijs, Peter J M (Lectoraat Voeding En Beweging); van Schaardenburg, Dirkjan

Objective To determine the effect of a multidisciplinary lifestyle program in patients with RA with low–moderate disease activity. Methods In the ‘Plants for Joints’ (PFJ) parallel-arm, assessor-blind randomized controlled trial, patients with RA and 28-joint DAS (DAS28) ≥2.6 and ≤5.1 were randomized …

2023-08AlgemeenArtikel

Additional effects of exercise to hypocaloric diet on body weight, body composition, glycaemic control and cardio-respiratory fitness in adults with overweight or obesity and type 2 diabetes

Memelink, Robert G. (Lectoraat Voeding En Beweging); Hummel, Mitchell; Hijlkema, Aveline; Streppel, Martinet T. (Lectoraat Voeding En Beweging); Bautmans, Ivan; Weijs, Peter J.M. (Lectoraat Voeding En Beweging); Berk, Kirsten A.; Tieland, Michael (Lectoraat Voeding En Beweging)

Aims: This systematic review and meta-analysis evaluates the additional effect of exercise to hypocaloric diet on body weight, body composition, glycaemic control and cardio-respiratory fitness in adults with overweight or obesity and type 2 diabetes. Methods: Embase, Medline, Web of Science and Cochrane …

2023-07AlgemeenAndersoortig materiaal

Effectiveness of a Lifestyle Intervention for People With a Severe Mental Illness in Dutch Outpatient Mental Health Care

Florine Walburg (Lid Lectoraat); Berno van Meijel (Lector); Trynke Hoekstra; Jelle Kol; Laura M. Pape; Johanna Willemina de Joode; Maurits van Tulder; Marcel C. Adriaanse

IMPORTANCE People with a severe mental illness (SMI) have a life expectancy reduced by 10 to 20 years compared with the general population, primarily attributable to cardiometabolic disorders. Lifestyle interventions for people with SMI can improve health and reduce cardiometabolic risk. OBJECTIVE To …

2023-06-21GezondheidArtikel

Feasibility Study to Assess Canagliflozin Distribution and Sodium-Glucose Co-Transporter 2 Occupancy Using [18F]Canagliflozin in Patients with Type 2 Diabetes

van der Hoek, Sjoukje; Willemsen, Antoon T.M.; Visser, Ton; Heeres, Andre (Biobased Chemistry & Refinery); Mulder, Douwe J.; Bokkers, Reinoud P.H.; Slart, Riemer H.J.A.; Elsinga, Philip H.; Heerspink, Hiddo J.L.; Stevens, Jasper

Sodium-glucose co-transporter 2 (SGLT2) inhibitors, including canagliflozin, reduce the risk of cardiovascular and kidney outcomes in patients with and without type 2 diabetes, albeit with a large interindividual variation. The underlying mechanisms for this variation in response might be attributed …

2023-03-10AlgemeenArtikel

Additional effects of exercise to hypocaloric diet on body weight, body composition, glycaemic control, and cardio-respiratory fitness in adults with overweight or obesity and type 2 diabetes: a systematic review and meta-analysis

Memelink, Robert (Lectoraat Voeding En Beweging); Hummel, Mitchell; Hijlkema, Aveline; Streppel, Martinet (Lectoraat Voeding En Beweging); Bautmans, Ivan; Weijs, Peter (Lectoraat Voeding En Beweging); Berk, Kirsten; Tieland, Michael (Lectoraat Voeding En Beweging)

BACKGROUND This systematic review and meta-analysis evaluates the additional effects of exercise to hypocaloric diet on body weight, body composition, glycaemic control, and cardio-respiratory fitness in adults with overweight or obesity and type 2 diabetes. METHODS Embase, Medline, Web of Science, and …

2022-11AlgemeenConferentiebijdrage

Increased species richness in the oral microbiome by a 13-week protein and combined lifestyle intervention in older adults with obesity and type 2 diabetes

Haji, M.; Memelink, R.G. (Lectoraat Voeding En Beweging); Brandt, B.W.; Buijs, M.J.; Pasman, W.J.; de Vogel-Van den Bosch, J.; Wopereis, S.; Zaura, E.; Weijs, P.J. (Lectoraat Voeding En Beweging)

Rationale: While combined lifestyle interventions have multiple health benefits, their impact on the oral microbiome is not known. We explored the effects of a lifestyle intervention including protein drink on the oral microbiome in older adults with obesity and type 2 diabetes (T2D). Methods: In a post-hoc …

2021-12AlgemeenArtikel

GMP Compliant Synthesis of Canagliflozin, a Novel PET Tracer for the Sodium−Glucose Cotransporter 2

Heeres, André (Biobased Chemistry & Refinery); van der Hoek, Sjoukje; Antunes, Inês F.; Attia, Khaled A.; Jacquet, Olivier; Bulthuis, Marian; Zijlma, Rolf; Boersma, Hendrikus H.; van Goor, Harry; Visser, Ton J.; Heerspink, Hiddo J. L.; Elsinga, Philip H.; Stevens, Jasper

Inhibition of the sodium−glucose cotransporter 2 (SGLT2) by canagliflozin in type 2 diabetes mellitus results in large between-patient variability in clinical response. To better understand this variability, the positron emission tomography (PET) tracer [18F]canagliflozin was developed via a Cu-mediated …

2021-11-08AlgemeenArtikel

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