Obesity is a growing global burden with numerous significant health implications, including a higher risk of developing Alzheimer’s disease (AD). This study investigates the role of obese adipose tissue on AD pathology in male APPswe/PSEN1-dE9 (APP/PSEN-1) transgenic mice, with a focus on cognitive decline, …

Introduction The Dutch Medical Doctor-Global Health (MD-GH) prepares to work in low-resource settings (LRS) by completing a hybrid postgraduate training program of 2 years and 9 months, with clinical and public health exposure in the Netherlands and a Global Health residency in LRS. The objectives of …

Background The number of Dutch clinical midwives has increased substantially over the last 20 years, but their tasks, responsibilities, and formal positions remain unclear. This study aimed to gain insight into the current tasks and responsibilities of clinical midwives in Dutch hospitals. We also aimed …

Rationale Bij bio-elektrische impedantieanalyse (BIA)-metingen wordt doorgaans een paar elektroden dorsaal op de rechterhand geplaatst (positie A) en een paar op de voet. Bij patiënten met kwetsbare huid, littekens of wonden is deze dorsale handplaatsing niet altijd mogelijk. Deze studie vergelijkt de …

Alzheimer's disease is a complex neurodegenerative disease and the most prevalent form of dementia. It affects every 14th person after the age of 65, thus making it a serious concern in modern society. Furthermore, currently available treatment is restricted only to symptomatic and is not highly effective. …

Background: Lung fibroblasts are implicated in abnormal tissue repair in chronic obstructive pulmonary disease (COPD). The exact mechanisms are unknown and comprehensive analysis comparing COPD- and control fibroblasts is lacking. Aim: To gain insight in the role of lung fibroblasts in COPD pathology …

Movement disorders in dementia are not well known yet they have a devastating effect on the quality of life and the abilities of a person with dementia. Paratonia is one of these movement disorders that are already present in 10% of the population with dementia in the early stages and increase up to …

SYNOPSIS: Neck pain, headache, and/ or orofacial symptoms are potentially the first (nonischemic) symptoms of an underlying vascular pathology or blood flow limitation. If an underlying vascular pathology or blood flow limitation is not recognized by the musculoskeletal rehabilitation clinician, it can …

Background: In face-to-face therapy for eating disorders, therapeutic alliance (TA) is an important predictor of symptomreduction and treatment completion. To date, however, little is known about TA during web-based cognitive behavioral therapy(web-CBT) and its association with symptom reduction, treatment …

Background: Tangential excision of burned tissue followed by skin grafting is the cornerstone of burn surgery. Hydrosurgery has become popular for tangential excision, with the hypothesis that enhanced preservation of vital dermal tissue reduces scarring. The aim of this trial was to compare scar quality …