Some of the most valuable companies in the world accumulated their fortunes as a result of a business model innovation built upon matured technologies. Now the majority of them are investing and shifting their focus to the development of new technologies such as AI, blockchain and genetic editing. If …

Canalization, an intrinsic robustness of development to external (environmental) or internal (genetic) perturbations, was first proposed over half a century ago. However, whether the robustness to environmental stress (environmental canalization [EC]) and to genetic variation (genetic canalization) are …

Stedin streeft als netbeheerder naar een betrouwbare dienstverlening tegen minimale kosten. Vermogenstransformatoren spelen hierbij een cruciale rol. Een veel gebruikte manier om de toestand van de vermogenstransformatoren te monitoren is de Dissolved Gas Analysis (DGA) op een oliemonster. De DGA-resultaten …

Aircraft require significant quantities of fuel in order to generate the power required to sustain a flight. Burning this fuel causes the release of polluting particles to the atmosphere and constitutes a direct cost attributed to fuel consumption. The optimization of various aircraft operations in different …

Bryophytes are small, haploid, non-vascular plants, which can be divided in three distinct phyla; the mosses (Musci), the liverworts (Hepaticae) and the hornworts (Anthocerotae) (Gradstein & Melick, 1996), (Touw, Kruijer, & Stech, 2016). They are valuable indicators of environmental chance, due to the …

Inleiding – Bij kinderen met het syndroom van Down (DS) is er sprake van primaire (genetische) en secundaire (niet genetische) problematieken in het mondgebied. De Nederlandse en Duitse richtlijnen zijn verschillend betreft de omgang met deze problematiek. Het doel van dit praktijkgerichte onderzoek …

For susceptible children, appropriate education and the right circumstances are of the utmost importance, even more than with "normal" children. In wrong circumstances things can easily go wrong. But under favourable conditions these people can reach the top. A bit like Formula 1 cars, which still have …

In this paper we present a data-driven profiling approach that we have adopted and implemented for a municipality. Our aim was to make profiles transparent and meaningful for citizens, policymakers and authorities so that they can validate, scrutinize and challenge the profiles. Our approach relies on …

Cutaneous melanoma is a type of skin cancer that develops from benign melanocytes to one of the most aggressive types of skin tumors in human. In cutaneous melanoma progression, the metastasis phase is the most challenging phase to treat. To enable earlier treatment options, a better understanding of …