Subject of this project is Alderney, one of the Channel Islands closest to France. The research brings into focus the traumatic World War II history of Alderney and the design aims to connect the present populace and public with this largely ignored past and to commemorate the victims. The sea plays …

Refugees deserve a humane and attentive reception when applying for asylum in the Netherlands. In this masterplan and design for the AZC in Budel full attention is paid to a stress reducing and welcoming environment for the applicants and the staff of the COA facilities. The integration in the site, …

Aim: We aim to gain insight into the interaction between challenging behavior as shown by individuals with an intellectual impairment, and space, and to explore the possibilities of using routinely collected data to this end. Background: Research on challenging behavior shown by intellectually impaired …

The recent advancements in machine learning (ML) techniques have significantly improved the performance in various natural language processing (NLP) tasks, particularly in deep learning with the transformer architecture. Despite their promising applications in different domains, these innovations have …

Despite tremendous efforts, the exact structure of SARS-CoV-2 and related betacoronaviruses remains elusive. SARS-CoV-2 envelope is a key structural component of the virion that encapsulates viral RNA. It is composed of three structural proteins, spike, membrane (M), and envelope, which interact with …

Aims Genetic hypertrophic cardiomyopathy (HCM) is caused by mutations in sarcomere protein-encoding genes (i.e. genotype-positive HCM). In an increasing number of patients, HCM occurs in the absence of a mutation (i.e. genotype-negative HCM). Mitochondrial dysfunction is thought to be a key driver of …

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