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Multivariate genome-wide analyses of the well-being spectrum

Baselmans, Bart M.L. (Faculteit Techniek (Ft)); Jansen, Rick; Ip, Hill F.; Abellaoui, Abdel; van de Weijer, Margot P.; Bao, Yanchun; Smart, Melissa; Kuni, Meena; Willemsen, Gonneke; Hottenga, Jouke-jan; Boomsma, Dorret I.; Nivard, Michel G.; Bartels, Meike; Dongen, Jenny van; Geus, Eco J.C. de

We introduce two novel methods for multivariate genome-wide-association meta-analysis (GWAMA) of related traits that correct for sample overlap. A broad range of simulation scenarios supports the added value of our multivariate methods relative to univariate GWAMA. We applied the novel methods to life …

2019-03-01AlgemeenArtikel

Lower birth weight is associated with alterations in dietary intake in adolescents independent of genetic factors

Doornweerd, Stieneke; IJzerman, Richard G.; Weijs, Peter J.M. (Lectoraat Voeding En Beweging); Diamant, Michaela; de Geus, Eco J.; Boomsma, Dorret I.

BACKGROUND & AIMS: Lower birth weight is associated with an increased risk of cardiovascular and metabolic disease. These associations may, at least in part, be explained by alterations in dietary intake in later life. The aim of this study is to examine whether lower birth weight is associated with …

2017-02AlgemeenArtikel

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Multivariate genome-wide analyses of the well-being spectrum

Lower birth weight is associated with alterations in dietary intake in adolescents independent of genetic factors

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