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Optimal Dosing and Timing of High-Dose Corticosteroid Therapy in Hospitalized Patients With COVID-19

Daenen, Katrijn; Huijben, Jilske A; Boyd, Anders; Bos, Lieuwe D J; Stoof, Sara C M; van Willigen, Hugo; Gommers, Diederik A M P J; Moeniralam, Hazra S; den Uil, Corstiaan A; Juffermans, Nicole P; Kant, Merijn; Valkenburg, Abraham J; Pillay, Janesh; van Meenen, David M P; Paulus, Frederique (Lectoraat Critical Care); Schultz, Marcus J; Dalm, Virgil A S H; van Gorp, Eric C M; Schinkel, Janke; Endeman, Henrik

Background: In hospitalized patients with COVID-19, the dosing and timing of corticosteroids vary widely. Low-dose dexamethasone therapy reduces mortality in patients requiring respiratory support, but it remains unclear how to treat patients when this therapy fails. In critically ill patients, high-dose …

2023-01AlgemeenArtikel

A closed-loop ventilation mode that targets the lowest work and force of breathing reduces the transpulmonary driving pressure in patients with moderate-to-severe ARDS

Buiteman-Kruizinga, Laura A.; van Meenen, David M. P.; Bos, Lieuwe D. J.; van der Heiden, Pim L. J.; Paulus, Frederique (Lectoraat Critical Care); Schultz, Marcus J.

Introduction The driving pressure (ΔP) has an independent association with outcome in patients with acute respiratory distress syndrome (ARDS). INTELLiVENT-Adaptive Support Ventilation (ASV) is a closed-loop mode of ventilation that targets the lowest work and force of breathing. Aim To compare transpulmonary …

2023AlgemeenArtikel

Practice of adjunctive treatments in critically ill COVID-19 patients-rational for the multicenter observational PRoAcT-COVID study in The Netherlands

Valk, Christel M. A.; Swart, Pien; Boers, Leonoor S.; Botta, Michela; Bos, Lieuwe D. J,; de Abreu, Marcelo Gama; Hol, Liselotte; Hollmann, Markus W.; Horn, Janneke; Martin-Loeches, Ignacio; Mazzinari, Guido; Myatra, Sheila N.; Nijbroek, Sunny G.; Rosenberg, Neeltje M.; Stilma, Willemke (Faculteit Gezondheid); Tsonas, Anissa M.; van der Ven, Ward H.; Neto, Ary Serpa; Schultz, Marcus J.; Paulus, Frederique

Background: Patients with coronavirus disease 2019 (COVID-19) may need hospitalization for supplemental oxygen, and some need intensive care unit (ICU) admission for escalation of care. Practice of adjunctive and supportive treatments remain uncertain and may vary widely between countries, within countries …

2021-05AlgemeenArtikel

Dead space estimates may not be independently associated with 28-day mortality in COVID-19 ARDS

Morales-Quinteros, Luis; Neto, Ary Serpa; Artigas, Antonio; Blanch, Lluis; Botta, Michela; Kaufman, David A.; Schultz, Marcus J.; Tsonas, Anissa M.; Paulus, Frederique; Bos, Lieuwe D.

BACKGROUND: Estimates for dead space ventilation have been shown to be independently associated with an increased risk of mortality in the acute respiratory distress syndrome and small case series of COVID-19-related ARDS. METHODS: Secondary analysis from the PRoVENT-COVID study. The PRoVENT-COVID is …

2021AlgemeenArtikel

Awake Proning as an Adjunctive Therapy for Refractory Hypoxemia in Non-Intubated Patients with COVID-19 Acute Respiratory Failure: Guidance from an International Group of Healthcare Workers

Stilma, Willemke (Faculteit Gezondheid); Åkerman, Eva; Artigas, Antonio; Bentley, Andrew; Bos, Lieuwe D.; Bosman, Thomas J. C.; de Bruin, Hendrik; Brummaier, Tobias; Buiteman-Kruizinga, Laura A.; Carcò, Francesco; Chesney, Gregg; Chu, Cindy; Dark, Paul; Dondorp, Arjen M.; Gijsbers, Harm J. H.; Gilder, Mary Ellen; Grieco, Domenico L.; Inglis, Rebecca; Laffey, John G.; Landoni, Giovanni; Lu, Weihua; Maduro, Lisa M. N.; McGready, Rose; McNicholas, Bairbre; de Mendoza, Diego; Morales-Quinteros, Luis; Nosten, Francois; Papali, Alfred; Paternoster, Gianluca; Paulus, Frederique (Lectoraat Critical Care); Pisani, Luigi; Prud'homme, Eloi; Ricard, Jean-Damien; Roca, Oriol; Sartini, Chiara; Scaravilli, Vittorio; Schultz, Marcus J.; Sivakorn, Chaisith; Spronk, Peter E.; Sztajnbok, Jaques; Trigui, Youssef; Vollman, Kathleen M.; van der Woude, Margaretha C. E.

Non-intubated patients with acute respiratory failure due to COVID-19 could benefit from awake proning. Awake proning is an attractive intervention in settings with limited resources, as it comes with no additional costs. However, awake proning remains poorly used probably because of unfamiliarity and …

2021AlgemeenArtikel

PRactice of VENTilation in Patients with Novel Coronavirus Disease (PRoVENT-COVID)

Boers, Noor S.; Botta, Michela; Tsonas, Annisa M.; Algera, Anna Geke; Pillay, Janesh; Dongelmans, Dave A.; Horn, Janneke; Vlaar, Alexander P. J.; Hollmann, Markus W.; Bos, Lieuwe D. J.; Paulus, Frederique (Lectoraat Critical Care); Neto, Ary Serpa; Schultz, Marcus J.

Background: The coronavirus disease 2019 (COVID-19) pandemic is rapidly expanding across the world, with more than 100,000 new cases each day as of end-June 2020. Healthcare workers are struggling to provide the best care for COVID-19 patients. Approaches for invasive ventilation vary widely between …

2020-10AlgemeenArtikel

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