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Cartilage tissue turnover increases with high- compared to low-intensity resistance training in patients with knee OA

Thudium, Christian S.; Engstrøm, Amalie; Bay-Jensen, Anne Christine; Frederiksen, Peder; Jansen, Nuria; De Zwart, Arjan; van der Leeden, Marike; Dekker, Joost; Lems, Willem; Roorda, Leo; van Spil, Willem Evert; Van der Esch, Martin (Lectoraat Interdisciplinaire Zorg Voor Chronische Gewrichtsaandoeningen)

Objectives To investigate cartilage tissue turnover in response to a supervised 12-week exercise-related joint loading training program followed by a 6-month period of unsupervised training in patients with knee osteoarthritis (OA). To study the difference in cartilage tissue turnover between high- and …

2023AlgemeenArtikel

Construct validity of the OCTOPuS stratification algorithm for allocating patients with knee osteoarthritis into subgroups

Knoop, Jesper; Ostelo, Raymond W. J. G.; van der Esch, Martin (Lectoraat Interdisciplinaire Zorg Voor Chronische Gewrichtsaandoeningen); de Zwart, Arjan; Bennell, Kim L.; van der Leeden, Marike; Dekker, Joost

BACKGROUND: We recently developed a model of stratified exercise therapy, consisting of (i) a stratification algorithm allocating patients with knee osteoarthritis (OA) into one of the three subgroups ('high muscle strength subgroup' representing a post-traumatic phenotype, 'low muscle strength subgroup' …

2021AlgemeenArtikel

The effect of high-intensity resistance training and vitamin D supplementation on muscle strength in patients with knee osteoarthritis: a randomized controlled trial

de Zwart, Arjan; Dekker, Joost; Roorda, Leo D.; van der Esch, Martin (Lectoraat Interdisciplinaire Zorg Voor Chronische Gewrichtsaandoeningen); Lips, Paul; van Schoor, Natasja; Heijboer, Annemieke; Turkstra, Franktien; Gerritsen, Martijn; Hakkinen, Arja; Bennell, Kim; Steultjens, Martijn; Lems, Willem; van der Leeden, Marike

Background Exercise therapy is the cornerstone of knee osteoarthritis (OA) management. In particular muscle strengthening exercise, targeting the characteristic loss of muscle strength present in knee OA, is a key factor for the beneficial effects reported for exercise therapy. The optimal training intensity …

2019-06AlgemeenArtikel

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Cartilage tissue turnover increases with high- compared to low-intensity resistance training in patients with knee OA

Construct validity of the OCTOPuS stratification algorithm for allocating patients with knee osteoarthritis into subgroups

The effect of high-intensity resistance training and vitamin D supplementation on muscle strength in patients with knee osteoarthritis: a randomized controlled trial

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