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Prophylactic exercises among head and neck cancer patients during and after swallowing sparing intensity modulated radiation: Adherence and exercise performance levels of a 12-week guided home-based program

Ingrid Cnossen (Lid Lectoraat); Cornelia F. van Uden-Kraan; Birgit I. Witte; Yke J. Aalders; Cees J.T. de Goede; Remco de Bree; Patricia Doornaert; Derek H.F. Rietveld; Jan Buter; Johannes A. Langendijk; C. René Leemans; Irma M. Verdonck-de Leeuw

The background and purpose of this paper is to investigate adherence, exercise performance levels and associated factors in head and neck cancer (HNC) patients participating in a guided home-based prophylactic exercise program during and after treatment [swallowing sparing intensity modulated radiation …

2017GezondheidArtikel

High prevalence of cachexia in newly diagnosed head and neck cancer patients: an exploratory study

Jager-Wittenaar, Harriët (Malnutrition And Healthy Ageing); Dijkstra, Pieter; Dijkstra, Gerard; Bijzet, Johan; Langendijk, Johannes A.; van der Laan, Bernard; Roodenburg, Jan

In patients with cancer, weight loss can be related to simple starvation, disturbed metabolism, or both. In patients with head and neck cancer (HNC), weight loss often is attributed to simple starvation because the obvious oral symptoms are known to hinder dietary intake. In this population, cachexia …

2017AlgemeenArtikel

Multivariable normal tissue complication probability model-based treatment plan optimization for grade 2-4 dysphagia and tube feeding dependence in head and neck radiotherapy

Kierkels, Roel G J; Wopken, Kim; Visser, Ruurd; Korevaar, Erik W; van der Schaaf, Arjen; Bijl, Hendrik P; Langendijk, Johannes A

BACKGROUND AND PURPOSE: Radiotherapy of the head and neck is challenged by the relatively large number of organs-at-risk close to the tumor. Biologically-oriented objective functions (OF) could optimally distribute the dose among the organs-at-risk. We aimed to explore OFs based on multivariable normal …

2016-12AlgemeenArtikel

Multicriteria optimization enables less experienced planners to efficiently produce high quality treatment plans in head and neck cancer radiotherapy

Kierkels, Roel G J; Visser, Ruurd; Bijl, Hendrik P; Langendijk, Johannes A; van 't Veld, Aart A; Steenbakkers, Roel J H M; Korevaar, Erik W

OBJECTIVES: To demonstrate that novice dosimetry planners efficiently create clinically acceptable IMRT plans for head and neck cancer (HNC) patients using a commercially available multicriteria optimization (MCO) system. METHODS: Twenty HNC patients were enrolled in this in-silico comparative planning …

2015-04-12AlgemeenArtikel

Evaluation of DVH-based treatment plan verification in addition to gamma passing rates for head and neck IMRT

Visser, Ruurd; Wauben, David J.L.; de Groot, Martijn; Steenbakkers, Roel J.H.M.; Godart, Jeremy; van 't Veld, Aart A.; Langendijk, Johannes A.; Korevaar, Erik W.; Bijl, Hendrik P

Background and purpose: Treatment plan verification of intensity modulated radiotherapy (IMRT) is generally performed with the gamma index (GI) evaluation method, which is difficult to extrapolate to clinical implications. Incorporating Dose Volume Histogram (DVH) information can compensate for this. …

2014-09-01AlgemeenArtikel

The impact of gastrointestinal and genitourinary toxicity on health related quality of life among irradiated prostate cancer patients

Schaake, Wouter (Healthy Ageing, Allied Health Care And Nursing); Wiegman, Erwin M.; de Groot, Martijn; van der Laan, Hans Paul; van der Schans, Cees (Healthy Ageing, Allied Health Care And Nursing); van den Bergh, Alfons C.M.; Langendijk, Johannes A.

PURPOSE: To determine the impact of late radiation-induced toxicity on health-related quality of life (HRQoL) among patients with prostate cancer. PATIENTS AND METHODS: The study sample was composed of 227 patients, treated with external beam radiotherapy. Common Terminology Criteria for Adverse Events …

2014-02-01AlgemeenArtikel

Validity of bioelectrical impedance analysis to assess fat-free mass in head and neck cancer patients

Jager-Wittenaar, Harriët (Malnutrition And Healthy Ageing); Dijkstra, Pieter; Earthman, Carrie; Krijnen, Wim (Statistical Techniques For Applied Research); Langendijk, Johannes; van der Laan, Bernard; Pruim, Jan; Roodenburg, Jan

Bioelectrical impedance analysis (BIA) may be used to assess fat free mass (FFM) with reasonable validity based on mean-level comparisons, but differences between BIA and DXA may vary by about 4 kg in an individual patient. These results require confirmation in a larger sample of HNC (Head and neck cancer) …

2014AlgemeenArtikel

Quality of life among prostate cancer patients: a prospective longitudinal population-based study

Schaake, Wouter (Healthy Ageing, Allied Health Care And Nursing); de Groot, Martijn; Krijnen, Wim (Statistical Techniques For Applied Research); Langendijk, Johannes A.; van den Bergh, Alfons C.M.

Purpose To investigate the course of quality of life (QoL) among prostate cancer patients treated with external beam radiotherapy and to compare the results with QoL of a normal age-matched reference population. Conclusion Prostate cancer patients experience a small worsening of QoL as compared with …

2013-08-01AlgemeenArtikel

Efficient and reliable 3D dose quality assurance for IMRT by combining independent dose calculations with measurements

Visser, Ruurd; Wauben, D.J.L.; de Groot, Martijn; Godart, Jeremy; Langendijk, Johannes A.; van't Veld, A.A.; Korevaar, Erik W.

PURPOSE: Advanced radiotherapy treatments require appropriate quality assurance (QA) to verify 3D dose distributions. Moreover, increase in patient numbers demand efficient QA-methods. In this study, a time efficient method that combines model-based QA and measurement-based QA was developed; i.e., the …

2013-01-18AlgemeenArtikel

Quality of life among prostate cancer survivors

Schaake, Wouter (Healthy Ageing, Allied Health Care And Nursing); de Groot, Martijn; Krijnen, Wim (Statistical Techniques For Applied Research); Langendijk, Johannes A.; van den Bergh, A.C.M.

Quality of life (QoL) of cancer patients after treatment may not only be affected by the treatment itself, but also by non-treatment related factors such as co-morbidity. As co-morbidity among prostate cancer patients is prevalent it is relevant to understand its impact on QoL. In this reagard, a comparison …

2013AlgemeenConferentiebijdrage

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