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Inter-individual variation in chlorpyrifos toxicokinetics characterized by physiologically based kinetic (PBK) and Monte Carlo simulation comparing human liver microsome and Supersome™ cytochromes P450 (CYP)-specific kinetic data as model input

Zhao, S.; Wesseling, S.; Rietjens, I.M.C.M.; Strikwold, M. (Lector)

The present study compares two approaches to evaluate the effects of inter-individual differences in the biotransformation of chlorpyrifos (CPF) on the sensitivity towards in vivo red blood cell (RBC) acetylcholinesterase (AChE) inhibition and to calculate a chemical-specific adjustment factor (CSAF) …

2022-03-16GezondheidArtikel

Selecting the dose metric in reverse dosimetry based QIVIVE

Rietjens, I.M.C.M.; Ning, J.; Chen, L.; Wesseling, S.; Strikwold, M. (Lector); Louisse, J.

Reply to ‘Comment on ‘Use of an in vitro–in silico testing strategy to predict inter-species and inter-ethnic human diferences in liver toxicity of the pyrrolizidine alkaloids lasiocarpine and riddelliine’ by Ning et al., Arch Toxicol doi: https://doi.org/10.1007/s00204-019-02397-7’, Arch Toxicol doi: …

2019GezondheidArtikel

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Inter-individual variation in chlorpyrifos toxicokinetics characterized by physiologically based kinetic (PBK) and Monte Carlo simulation comparing human liver microsome and Supersome™ cytochromes P450 (CYP)-specific kinetic data as model input

Selecting the dose metric in reverse dosimetry based QIVIVE

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