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Ai Meets scRNA-seq: Leveraging Large Language Models for Context-Aware Lung Cell Type Annotation

Feenstra, Fenna; Ramihof, Marjan

2025-10-02AlgemeenConferentiebijdrage

The influence of ROS1 fusion partners and resistance mechanisms in ROS1-TKI-treated non-small cell lung cancer patients

Zwierenga, Fenneke; Dijkhuizen, Christa (Biomolecules & Health); Korthuis, Patrick; Timens, Wim; Groen, Harry; Hiltermann, Jeroen; van den Berg, Anke; Drayer, Lyndsay; van der Wekken, Anthonie

Clinical outcomes in ROS1-fusion positive (ROS1+) non-small cell lung cancer (NSCLC) by fusion partner and resistance mechanisms are limited. This cohort study included 56 ROS1+ patients (FISH or NGS confirmed); fusion partners were identified in 27 cases, including CD74 (n = 10), EZR (n = 7), and SDC4 …

2025-08-29GezondheidArtikel

Promising patient experiences with a smartphone app and remote coaching for improving physical activity and protein intake to enhance recovery after oncological surgery: a multi-methods study

van Westerhuis, C. (Lectoraat Fysiotherapie -Bewegen Naar Preventieve Zorg); De Leeuwerk, M. E.; van der Werf, E. W. J.; Kruizenga, H. M.; de Groot, V.; Geleijn, E.; van der Leeden, M.; van der Schaaf, M. (Lectoraat Revalidatie Bij Complexe Zorg)

Purpose The Optimal Physical Recovery After Hospitalization (OPRAH) Intervention is a blended intervention, combining a smartphone app for self-monitoring of physical activity and protein intake with coaching from a physiotherapist and dietician, to enhance the functional recovery after gastro-intestinal …

2025-07AlgemeenArtikel

Variations in vertebral muscle mass and muscle quality in adult patients with different types of cancer

Sealy, Martine J (Healthy Ageing, Allied Health Care And Nursing); Van den Broeck, Jona; Brussaard, Carola; Scafoglieri, Aldo; Jager-Wittenaar, Harriët (Healthy Ageing, Allied Health Care And Nursing); Kunstman, Birgit

OBJECTIVES: Assessment of malnutrition-related muscle depletion with computed tomography (CT) using skeletal muscle index (SMI) and muscle radiation attenuation (MRA) at the third lumbar vertebra is well validated. However, SMI and MRA values at other vertebral locations and interchangeability as parameters …

2024-12-01AlgemeenArtikel

The efficacy of a blended intervention to improve physical activity and protein intake for optimal physical recovery after oncological gastrointestinal and lung cancer surgery, the Optimal Physical Recovery After Hospitalization (OPRAH) trial

de Leeuwerk, Marijke; de Groot, Vincent; Dam, Suzanne ten; Kruizenga, Hinke; Weijs, Peter (Lectoraat Voeding En Beweging); Geleijn, Edwin; van der Leeden, Marike; van der Schaaf, Marike (Lectoraat Revalidatie Bij Complexe Zorg); Dickhoff, Chris; Besselink, Marc G.; Tuynman, Jurriaan B.; van Berge Henegouwen, Mark I.; Erdmann, Joris I.; Huijsmans, Rosalie J.; van der Ploeg, Hidde P.; Eskes, Anne M. (Lectoraat Patiënt- En Familieparticipatie In De Klinische Zorg); Pijnappels, Mirjam A.G.M.; van Leeuwen, Liesbeth Schuijs; Smits, Anke B.; van Dijk, Jasmijn; Grimbergen, Eva

Background: Improving physical activity, especially in combination with optimizing protein intake, after surgery has a potential positive effect on recovery of physical functioning in patients after gastrointestinal and lung cancer surgery. The aim of this randomized controlled trial is to evaluate the …

2023-11-27AlgemeenArtikel

L2026M+G2032R variant confers resistance to ROS1 tyrosine kinase inhibitors in SCL34A2-ROS1 overexpressing Ba/F3 cells through a reduced ATP binding pocket volume

Dijkhuizen, Christa (Biomolecules & Health); Korthuis, Patrick; Vilachã, Juliana F.; Smelt, Maaike; van der Wekken, Anthonie; van den Berg, Anke; Drayer, Lyndsay

Background The ROS1 G2032R mutation is the most common on-target resistance mutation in crizotinib treated ROS1-positive lung cancer patients. The aim of our study was to investigate resistance mechanisms in SCL34A2-ROS1G2032R positive Ba/F3 cells against second line treatment with lorlatinib. Methods …

2023-10-21GezondheidConferentiebijdrage

The correlation of muscle quantity and quality between all vertebra levels and level L3, measured with CT

Van den Broeck, Jona; Sealy, Martine J (Healthy Ageing, Allied Health Care And Nursing); Brussaard, Carola; Jager-Wittenaar, Harriët (Healthy Ageing, Allied Health Care And Nursing); Scafoglieri, Aldo; Kooijman, Jasmijn

INTRODUCTION: In patients with cancer, low muscle mass has been associated with a higher risk of fatigue, poorer treatment outcomes, and mortality. To determine body composition with computed tomography (CT), measuring the muscle quantity at the level of lumbar 3 (L3) is suggested. However, in patients …

2023-02-23AlgemeenArtikel

Self-monitoring of physical activity after hospital discharge in patients who have undergone gastrointestinal or lung cancer surgery

de Leeuwerk, Marijke Elizabeth; Botjes, Martine; van Vliet, Vincent; Geleijn, Edwin; de Groot, Vincent; van Wegen, Erwin; van der Schaaf, Marike (Faculteit Gezondheid); Tuynman, Jurriaan; Dickhoff, Chris; van der Leeden, Marike

BACKGROUND: Self-monitoring of physical activity (PA) using an accelerometer is a promising intervention to stimulate PA after hospital discharge. OBJECTIVE: This study aimed to evaluate the feasibility of PA self-monitoring after discharge in patients who have undergone gastrointestinal or lung cancer …

2022-06-24AlgemeenArtikel

Does muscle mass measured with Computed Tomography analysis differ in patients with different types of cancer?

Sealy, Martine (Malnutrition And Healthy Ageing); Van den Broeck, Jona; Brussaard, Carola; Scafoglieri, Aldo; Jager-Wittenaar, Harriët (Malnutrition And Healthy Ageing)

Rationale: Patients with cancer of the upper gastrointestinal tract or lung are more likely to present with malnutrition at diagnosis than, for instance, patients with melanoma. Low muscle mass is an indicator of malnutrition and can be determined by computed tomography (CT) analysis of the skeletal …

2021-12-01Gezondheid; …Conferentiebijdrage

Ondervoeding bij NSCLC-stadium III

Amarins Koster (Student); Tessa Sluiter (Student); Wouter Schaake (Begeleider); Esther Gerbers-van den Heuvel (Begeleider)

Het doel van dit onderzoek is om te identificeren welke factoren invloed hebben op het gewichtsverlies tijdens de chemoradiatie van patiënten met NSCLC-stadium III. Door deze factoren te bepalen, kan hier mogelijk preventief op worden ingespeeld tijdens het behandelproces. Van de NSCLC-stadium III patiënten …

2020-06-08GezondheidBachelor

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