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The TNFR1 antagonist Atrosimab reduces neuronal loss, glial activation and memory deficits in an acute mouse model of neurodegeneration

Ortí-Casañ, N.; Boerema, A.S. (Lid Lectoraat); Köpke, K.; Ebskamp, A.; Keijser, J.; Zhang, Y.; Chen, T.; Dolga, A.M.; Broersen, K.; Fischer, R.; Pfizenmaier, K.; Kontermann, R.E.; Eisel, U.L.M.

Tumor necrosis factor alpha (TNF-α) and its key role in modulating immune responses has been widely recognized as a therapeutic target for inflammatory and neurodegenerative diseases. Even though inhibition of TNF-α is beneficial for the treatment of certain inflammatory diseases, total neutralization …

2023-06-30GezondheidArtikel

Dutch translation and validation of the Communicative Participation Item Bank (CPIB)—short form

van Sluis, Klaske E.; Passchier, Ellen; van Son, Rob J. J. H.; van der Molen, Lisette; Stuiver, Martijn (Lectoraat Functioneel Herstel Bij Kanker); van den Brekel, Michiel W. M.; Van den Steen, Leen; Kalf, Johanna G.; van Nuffelen, Gwen

Background Several conditions and diseases can result in speech problems that can have a negative impact on everyday functioning, referred to as communicative participation. Subjective problems with acquired speech problems are often assessed with the speech handicap index (SHI). To assess generic participation …

2023-01AlgemeenArtikel

Experienced complaints, activity limitations and loss of motor capacities in patients with pure hereditary spastic paraplegia: a web-based survey in the Netherlands

B.J.H. van Lith; Hans Kerstens; LAC van den Bemd; Ria Nijhuis-van der Sanden; V. Weerdesteyn; R.J.E.M. Smeets; K Fheodoroff; BPC van de Warrenburg; A.C.H. Geurts

Background Hereditary spastic paraplegia (HSP) is a group of inherited disorders characterized by progressive spastic paresis of the lower limbs. Treatment is often focused on reducing spasticity and its physical consequences. To better address individual patients' needs, we investigated a broad range …

2020AlgemeenArtikel

Perspectives on theory and application of implicit and explicit motor learning in neurological rehabilitation

Melanie Kleynen (Phd)

Movement is an essential part of our lives. Throughout our lifetime, we acquire many different motor skills that are necessary to take care of ourselves (e.g., eating, dressing), to work (e.g., typing, using tools, care for others) and to pursue our hobbies (e.g., running, dancing, painting). However, …

2018GezondheidProefschrift

The clinimetric properties of the COMFORT scale: a systematic review

Maaskant, J.; Raymakers-Janssen, P.; Veldhoen, E.; Ista, E.; Lucas, C.; Vermeulen, H.

The COMFORT scale is a measurement tool to assess distress, sedation and pain in nonverbal paediatric patients. Several studies have described the COMFORT scale, but no formal assessment of the methodological quality has been undertaken. Therefore, we performed a systematic review to study the clinimetric …

2016-11AlgemeenArtikel

Idiopathic toe-walking in children, adolescents and young adults: a matter of local or generalised stiffness?

Engelbert, Raoul (Lectoraat Fysiotherapie - Transitie Van Zorg Bij Complexe Patiënten); Gorter, Jan Willem; Uiterwaal, Cuno; van de Putte, Elise; Helders, Paul

Background Idiopathic Toe Walking (ITW) is present in children older than 3 years of age still walking on their toes without signs of neurological, orthopaedic or psychiatric diseases. ITW has been estimated to occur in 7% to 24% of the childhood population. To study associations between Idiopathic Toe …

2011AlgemeenArtikel

Het effect van klassieke massagetherapie op circulatiestoornis mobiliteitsverandering, pijn en verandering in tonus : een systematische review

David de Louw (Begeleider); Ariënne Holla (Student); Linda Swinkels (Student); Chiara Blom (Student); Gé de Bruin (Begeleider); Imke van Rees (Student)

Soort onderzoek: literatuuronderzoek, middels een systematische review. Onderzoeksvraag: wat zijn de wetenschappelijk bewezen effecten van klassieke massagetherapie op circulatiestoornis, mobiliteitsverandering, pijn en verandering in tonus bij patiënten van negentien jaar en ouder met orthopedische …

2003GezondheidBachelor

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