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Skeletal muscle uncoupling protein-3 restores upon intervention in the pre-diabetic and diabetic state: implications for diabetes pathogenesis?

L.B. Borghouts (Lector); E. Moonen-Kornips; Schaart; M. Mensink; M.K.C. Hesselink; H.A. Keizer; Blaak; Schrauwen

Both exercise training and a lifestyle-intervention program increase UCP3 protein content inskeletal muscle of subjects with reduced glycaemic control, indicating a restoration towards normal UCP3 levels. These data support the idea that UCP3 has a role in the aetiology of type 2 diabetes mellitus

2007GezondheidArtikel

Protein expression of UCP3 differs between human type 1, type 2a and type 2 fibers.

G. Schaart; M.K.C. Hesselink; C.F.P. Kornips; P. Schrauwen; W.H.M. Saris; L.B. Borghouts (Lector); L.J. Slieker; K.W. Sloop; H.A. Keizer

Muscle fiber-type specific expression of UCP3-protein is reported here for the firts time, using immunofluorescence microscopy

2001AlgemeenArtikel

Uncoupling Protein 3 Content Is Decreased in Skeletal Muscle of Patients With Type 2 Diabetes

Keizer; E.E. Blaak; P. Schrauwen; G. Schaart; L.B. Borghouts (Lector); Saris; M.K.C. Hesselink

Recently, a role for uncoupling protein-3 (UCP3) in carbohydrate metabolism and in type 2 diabetes has been suggested. Mice overexpressing UCP3 in skeletal muscle showed reduced fasting plasma glucose levels, improved glucose tolerance after an oral glucose load, and reduced fasting plasma insulin levels. …

2001GezondheidArtikel

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Skeletal muscle uncoupling protein-3 restores upon intervention in the pre-diabetic and diabetic state: implications for diabetes pathogenesis?

Protein expression of UCP3 differs between human type 1, type 2a and type 2 fibers.

Uncoupling Protein 3 Content Is Decreased in Skeletal Muscle of Patients With Type 2 Diabetes

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