Insulin sensitivity and metabolic flexibility decrease in response to bed rest, but the temporal and causal adaptations in human skeletal muscle metabolism are not fully defined. Here, we use an integrative approach to assess human skeletal muscle metabolism during bed rest and provide a multi-system …

The European Society for Clinical Nutrition and Metabolism (ESPEN) and the European Association for the Study of Obesity (EASO) launched the Sarcopenic Obesity Global Leadership Initiative (SOGLI) to reach expert consensus on a definition and diagnostic criteria for Sarcopenic Obesity (SO). The present …

This booklet shows the urban metabolism of five different cities around the globe. From small, Venice, to extra large, New York. We took the city as the human body; integral, dependent on multiple organs and based on comprehensive flows. Mobility, typology, nature and history go hand in hand in the total …

The design of cities has long ignored the flows that shape the city. Water has been the most visible one, but energy and materials were invisible and/or taken for granted. A little over 50 years ago, Abel Wolman was the first to illuminate the role of water flows in the urban fabric. It has long been …

The disruption of nutrient cycles caused by human activities such as agriculture and burning fossil fuels is impacting ecosystem services on global and local scales. The increasing concentration of carbon dioxide in the atmosphere contributes to rising global temperatures and ocean acidification, whereas …