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Effect of high versus standard protein provision on functional recovery in people with critical illness (PRECISe)

Bels, Julia L M; Thiessen, Steven; van Gassel, Rob J J; Beishuizen, Albertus; De Bie Dekker, Ashley; Fraipont, Vincent; Lamote, Stoffel; Ledoux, Didier; Scheeren, Clarissa; De Waele, Elisabeth; van Zanten, Arthur R H; Bormans-Russell, Laura; van Bussel, Bas C T; Dictus, Marlies M J; Fivez, Tom; Harks, Ingeborg; van der Horst, Iwan C C; Jonckheer, Joop; Marechal, Hugues; Massion, Paul B; Meex, Ingrid; Paulus, Michelle C; Rinket, Martin; van Santen, Susanne; Tartaglia, Katrien; Deane, Adam M; Demuydt, Frieda; Puthucheary, Zudin; Vloet, Lilian C M; Weijs, Peter J M (Lectoraat Voeding En Beweging); van Kuijk, Sander M J; van de Poll, Marcel C G; Mesotten, Dieter

Background Increased protein provision might ameliorate muscle wasting and improve long-term outcomes in critically ill patients. The aim of the PRECISe trial was to assess whether higher enteral protein provision (ie, 2·0 g/kg per day) would improve health-related quality of life and functional outcomes …

2024-08-17AlgemeenArtikel

The efficacy of a blended intervention to improve physical activity and protein intake for optimal physical recovery after oncological gastrointestinal and lung cancer surgery, the Optimal Physical Recovery After Hospitalization (OPRAH) trial

de Leeuwerk, Marijke; de Groot, Vincent; Dam, Suzanne ten; Kruizenga, Hinke; Weijs, Peter (Lectoraat Voeding En Beweging); Geleijn, Edwin; van der Leeden, Marike; van der Schaaf, Marike (Lectoraat Revalidatie Bij Complexe Zorg); Dickhoff, Chris; Besselink, Marc G.; Tuynman, Jurriaan B.; van Berge Henegouwen, Mark I.; Erdmann, Joris I.; Huijsmans, Rosalie J.; van der Ploeg, Hidde P.; Eskes, Anne M. (Lectoraat Patiënt- En Familieparticipatie In De Klinische Zorg); Pijnappels, Mirjam A.G.M.; van Leeuwen, Liesbeth Schuijs; Smits, Anke B.; van Dijk, Jasmijn; Grimbergen, Eva

Background: Improving physical activity, especially in combination with optimizing protein intake, after surgery has a potential positive effect on recovery of physical functioning in patients after gastrointestinal and lung cancer surgery. The aim of this randomized controlled trial is to evaluate the …

2023-11-27AlgemeenArtikel

Incisional negative pressure wound therapy for the prevention of surgical site infection

Groenen, Hannah; Jalalzadeh, Hasti; Buis, Dennis R.; Dreissen, Yasmine E.M.; Goosen, Jon H.M.; Griekspoor, Mitchel; Harmsen, Wouter J.; IJpma, Frank F.A.; van der Laan, Maarten J.; Schaad, Roald R.; Segers, Patrique; van der Zwet, Wil C.; de Jonge, Stijn W.; Orsini, Ricardo G.; Eskes, Anne M. (Lectoraat Patiënt- En Familieparticipatie In De Klinische Zorg); Wolfhagen, Niels; Boermeester, Marja A.

BACKGROUND: The evidence on prophylactic use of negative pressure wound therapy on primary closed incisional wounds (iNPWT) for the prevention of surgical site infections (SSI) is confusing and ambiguous. Implementation in daily practice is impaired by inconsistent recommendations in current international …

2023-08AlgemeenArtikel

Feasibility of inspiratory muscle training for patients with persistent dyspnea after COVID-19 infection

Collet, Romain; van Egmond, Maarten (Lectoraat Fysiotherapie -Bewegen Naar Preventieve Zorg); van der Schaaf, Marike (Lectoraat Revalidatie Bij Complexe Zorg); Major-Helsloot, Mel (Urban Vitality)

Objective This study investigates the feasibility of delivering inspiratory muscle training as part of the physical therapy treatment for patients with post-COVID dyspnoea. Design Mixed-methods pilot study. Subjects/patients Patients with complaints of dyspnoea after COVID-19 infection and their physical …

2023-06-05AlgemeenArtikel

Evidence for effect of l-serine, a novel therapy for GRIN2B-related neurodevelopmental disorder.

B. den Hollander; A.R.J. Veenvliet; Marieke Lindenschot; P. van Essen; G. Peters; A. Santos-Gómez; M. Olivella; X. Altafaj; M.M. Brands; B.A.W. Jacobs; C.D. van Karnebeek

RATIONALE: To date, causal therapy is potentially available for GRIN2B-related neurodevelopmental disorder (NDD) due to loss-of-function (LoF) variants in GRIN2B, resulting in dysfunction of the GluN2B subunit-containing N-methyl-d-aspartate receptor (NMDAR). Recently, in vitro experiments showed that …

2023AlgemeenArtikel

Patient outcomes before and after implementation of a selective pre-hospital spinal immobilization protocol

Otto van de Breevaart (Onderzoeker); Nancy van de Waarden (Onderzoeker); Lisette Schoonhoven (Onderzoeker); Wietske Blom-Ham (Onderzoeker); Niels Schep (Onderzoeker)

Background: A new selective preventive spinal immobilization (PSI) protocol was introduced in the Netherlands. This may have led to an increase in non-immobilized spinal fractures (NISFs) and consequently adverse patient outcomes. Aim: A pilot study was conducted to describe the adverse patient outcomes …

2023GezondheidArtikel

Stromal vascular fraction-enriched fat grafting as treatment of adherent scars

Vriend, Linda; van Dongen, Joris A; Pijpe, Anouk; Nieuwenhuis, Marianne K. (Healthy Ageing, Allied Health Care And Nursing); Jongen, Sandra J.M.; Harmsen, Martin C; van Zuilen, Paul P.M.; van der Lei, Berend

BACKGROUND: In the last decades, autologous fat grafting has been used to treat adherent dermal scars. The observed regenerative and scar-reducing properties have been mainly ascribed to the tissue-derived stromal vascular fraction (tSVF) in adipose tissue. Adipose tissue's components augment local angiogenesis …

2022-12-01AlgemeenArtikel

Hydrosurgical and conventional debridement of burns

HyCon Study Group

Background: Tangential excision of burned tissue followed by skin grafting is the cornerstone of burn surgery. Hydrosurgery has become popular for tangential excision, with the hypothesis that enhanced preservation of vital dermal tissue reduces scarring. The aim of this trial was to compare scar quality …

2022-03-03AlgemeenArtikel

CCT: continuous care trial - a randomized controlled trial of the provision of continuous care during labor by maternity care assistants in the Netherlands

Adrie Lettink; Karina Chaibekava; Luc J.M. Smits; Josje Langenveld; Rafli van de Laar; Babette Peeters; Marie-Louise Verstappen; Carmen Dirksen; Marianne Nieuwenhuijze (Lector); Hubertina Scheepers

Background: In 2009, the Steering Committee for Pregnancy and Childbirth in the Netherlands recommended the implementation of continuous care during labor in order to improve perinatal outcomes. However, in current care, routine maternity caregivers are unable to provide this type of care, resulting …

2020-11-25GezondheidArtikel

Physiotherapy With Telerehabilitation in Patients With Complicated Postoperative Recovery After Esophageal Cancer Surgery: Feasibility Study

van Egmond, Maarten A; Engelbert, Raoul H H (Faculteit Gezondheid); Klinkenbijl, Jean H G; van Berge Henegouwen, Mark I; van der Schaaf, Marike (Faculteit Gezondheid)

Background: Improvement of functional status with physiotherapy is an important goal for patients with postoperative complications and an increased length of hospital stay (LoS) after esophagectomy. Supervised physiotherapy with telerehabilitation instead of conventional face-to-face care could be an …

2020-06AlgemeenArtikel

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