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Biotransformation-mediated synthesis of (1S)-1-(2,6-dichloro-3- fluorophenyl)ethanol in enantiomerically pure form

Martinez, Carlos A.; Meijer, Renzo; Metselaar, Gerard; Kruithof, Gerlof; Moore, Curtis; Kung, Pei Pei; Keller, Erik (Biorefinery)

An efficient four-step biotransformation-mediated synthesis of (1S)-1-(2,6-dichloro-3-fluorophenyl)ethanol in enantiomerically pure form is described. This compound is a key intermediate required for the preparation of PF-2341066, a potent inhibitor of c-Met/ALK that is currently in clinical development. …

2010-10-07AlgemeenArtikel

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Biotransformation-mediated synthesis of (1S)-1-(2,6-dichloro-3- fluorophenyl)ethanol in enantiomerically pure form

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