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Inter-individual variation in chlorpyrifos toxicokinetics characterized by physiologically based kinetic (PBK) and Monte Carlo simulation comparing human liver microsome and Supersome™ cytochromes P450 (CYP)-specific kinetic data as model input

Zhao, S.; Wesseling, S.; Rietjens, I.M.C.M.; Strikwold, M. (Lector)

The present study compares two approaches to evaluate the effects of inter-individual differences in the biotransformation of chlorpyrifos (CPF) on the sensitivity towards in vivo red blood cell (RBC) acetylcholinesterase (AChE) inhibition and to calculate a chemical-specific adjustment factor (CSAF) …

2022-03-16GezondheidArtikel

Application of Caenorhabditis elegans (nematode) and Danio rerio embryo (zebrafish) as model systems to screen for developmental and reproductive toxicity of Piperazine compounds

Peter I. Racza (Onderzoeker); Marjolein Wildwater (Onderzoeker); Martijn Rooseboom (Onderzoeker); Engelien Kerkhof (Onderzoeker); Raymond Pieters (Lector); Elena Santidrian Yebra-Pimentela (Onderzoeker); Ron P. Dirks (Onderzoeker); Herman P. Spaink (Onderzoeker); Chantal Smulders (Onderzoeker); Graham F. Whale (Onderzoeker)

From the article: "To enable selection of novel chemicals for new processes, there is a recognized need for alternative toxicity screening assays to assess potential risks to man and the environment. For human health hazard assessment these screening assays need to be translational to humans, have …

2017-06-27GezondheidArtikel

Biotransformation-mediated synthesis of (1S)-1-(2,6-dichloro-3- fluorophenyl)ethanol in enantiomerically pure form

Martinez, Carlos A.; Meijer, Renzo; Metselaar, Gerard; Kruithof, Gerlof; Moore, Curtis; Kung, Pei Pei; Keller, Erik (Biorefinery)

An efficient four-step biotransformation-mediated synthesis of (1S)-1-(2,6-dichloro-3-fluorophenyl)ethanol in enantiomerically pure form is described. This compound is a key intermediate required for the preparation of PF-2341066, a potent inhibitor of c-Met/ALK that is currently in clinical development. …

2010-10-07AlgemeenArtikel

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Inter-individual variation in chlorpyrifos toxicokinetics characterized by physiologically based kinetic (PBK) and Monte Carlo simulation comparing human liver microsome and Supersome™ cytochromes P450 (CYP)-specific kinetic data as model input

Application of Caenorhabditis elegans (nematode) and Danio rerio embryo (zebrafish) as model systems to screen for developmental and reproductive toxicity of Piperazine compounds

Biotransformation-mediated synthesis of (1S)-1-(2,6-dichloro-3- fluorophenyl)ethanol in enantiomerically pure form

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