Biotransformation-mediated synthesis of (1S)-1-(2,6-dichloro-3- fluorophenyl)ethanol in enantiomerically pure form
Biotransformation-mediated synthesis of (1S)-1-(2,6-dichloro-3- fluorophenyl)ethanol in enantiomerically pure form
Summary
An efficient four-step biotransformation-mediated synthesis of (1S)-1-(2,6-dichloro-3-fluorophenyl)ethanol in enantiomerically pure form is described. This compound is a key intermediate required for the preparation of PF-2341066, a potent inhibitor of c-Met/ALK that is currently in clinical development. The described synthesis was used to manufacture 6 kg of the title compound and can also be employed to produce the corresponding (1R)-enantiomer. © 2010 Elsevier Ltd. All rights reserved.
| Organisation | Hanze |
| Published in | Tetrahedron: asymmetry Elsevier, Vol. 21, Uitgave: 19, Pagina's: 2408-2413 |
| Date | 2010-10-07 |
| Type | Journal article |
| DOI | 10.1016/j.tetasy.2010.09.007 |
| Language | English |
