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Dysphagia, trismus and speech impairment following radiation-based treatment for advanced stage oropharyngeal carcinoma: a one-year prospective evaluation

Karsten, Rebecca T.; Chargi, Najiba; van der Molen, Lisette; van Son, Rob J. J. H.; de Bree, Remco; Al-Mamgani, Abrahim; de Boer, Jan P.; Hilgers, Frans J. M.; van den Brekel, Michiel W. M.; Smeele, Ludi E.; Stuiver, Martijn M. (Lectoraat Functioneel Herstel Bij Kanker)

OBJECTIVE: The objective was to assess swallowing, mouth opening and speech function during the first year after radiation-based treatment (RT(+)) after introduction of a dedicated preventive rehabilitation program for stage III-IV oropharyngeal carcinoma (OPC). METHODS: Swallowing, mouth opening and …

2022AlgemeenArtikel

The efficacy of lyticase and β-glucosidase enzymes on biofilm degradation of Pseudomonas aeruginosa strains with different gene profiles

Maryam Banar (Onderzoeker); Mohammad Emaneini (Onderzoeker); Reza Beigverdi (Onderzoeker); Rima Fanaei Pirlar (Onderzoeker); Narges Node Farahani (Onderzoeker); Willem van Leeuwen (Lector); Fereshteh Jabalameli (Onderzoeker)

Background: Pseudomonas aeruginosa is a nosocomial pathogen that causes severe infections in immunocompromised patients. Biofilm plays a significant role in the resistance of this bacterium and complicates the treatment of its infections. In this study, the effect of lyticase and β-glucosidase enzymes …

2019Natuur & LandbouwArtikel

Een dosisvergelijking tussen Inspiration Breath Hold en 4DCT bij patiënten met Non Small Cell Lung Carcinoma stadium III

Gemma van der Sluijs (Student); Mariette Raadsen (Begeleider)

Bestraling van longtumoren blijft een voortdurende uitdaging door beweging tijdens ademhaling (1). Een tumor kan, afhankelijk van de locatie, tot wel 20 millimeter bewegen in inferior-superior richting (2). Een afname van deze beweging kan resulteren in een lagere dosis in omliggende organen, ofwel Organs …

2019GezondheidBachelor

Long-term tumor-free survival in a metastatic pancreatic carcinoma patient with FOLFIRINOX/Mitomycin, high-dose, fever inducing Viscum album extracts and subsequent R0 resection

Paul G. Werthmann (Onderzoeker); Pia Inter (Onderzoeker); Thilo Welsch (Onderzoeker)

Rationale: Metastatic pancreatic cancer has a dismal prognosis. Many patients seek integrative care as an add-on to their conventional cancer treatment. Viscum album extracts (VAE)—widely used as an adjunct to cancer treatment—have cytotoxic, apoptogenic, and immune stimulatory properties. A statistically …

2018-10-22GezondheidArtikel

A 21-year course of Merkel cell carcinoma with adjuvant Viscum album extract treatment

Paul G. Werthmann (Onderzoeker); Lothar Kindermann (Onderzoeker); Gunver S. Kienle (Onderzoeker)

Background Merkel cell carcinoma (MCC) is a rare, aggressive, neuroendocrine skin tumor with frequent local recurrence, lymph node involvement, distant metastasis, and a high mortality rate. Viscum album extracts (VAE) are a widely used adjunct in cancer treatment and show cytotoxic and immune-modulating …

2018-04-09GezondheidArtikel

Durable clinical remission of a skull metastasis under intralesional Viscum album extract therapy

Paul G. Werthmann (Onderzoeker); Roman Huber (Onderzoeker); Gunver S. Kienle (Onderzoeker)

Background Skull metastases are rare, they can eventually cause pain, and can invade the brain. Viscum album extracts (VAEs) are used as an adjuvant treatment in cancer. Methods and Results A 68‐year‐old patient with rectal cancer presented with lung metastases, and metastases to multiple bone sites, …

2018GezondheidArtikel

Evaluation of Mannosidase and Trypsin Enzymes Effects on Biofilm Production of Pseudomonas aeruginosa Isolated from Burn Wound Infections

Maryam Banar (Onderzoeker); Mohammad Emaneini (Onderzoeker); Mhboubeh Satarzadeh (Onderzoeker); Nafiseh Abdellahi (Onderzoeker); Reza Beigverdi (Onderzoeker); Willem van Leeuwen (Lector); Fereshteh Jabalameli (Onderzoeker)

Biofilm is an important virulence factor in Pseudomonas aeruginosa and has a substantial role in antibiotic resistance and chronic burn wound infections. New therapeutic agents against P. aeruginosa, degrading biofilms in burn wounds and improving the efficacy of current antimicrobial agents, are required. …

2016-10-13Natuur & LandbouwArtikel

Health services research of integrative oncology in palliative care of patients with advanced pancreatic cancer

Jan Axtner (Onderzoeker); Megan L. Steele (Onderzoeker); Matthias Kröz (Onderzoeker); Günther Spahn (Onderzoeker); Harald Matthes (Onderzoeker); Friedemann Schad (Onderzoeker)

Background: Pancreatic cancer has a dire prognosis and is associated with a high mortality. Palliative patients have special needs and often seek help in integrative oncological concepts (IO) that combine conventional and complementary therapies. Nevertheless there are few recommendations regarding IO …

2016-08-02GezondheidArtikel

Multicriteria optimization enables less experienced planners to efficiently produce high quality treatment plans in head and neck cancer radiotherapy

Kierkels, Roel G J; Visser, Ruurd; Bijl, Hendrik P; Langendijk, Johannes A; van 't Veld, Aart A; Steenbakkers, Roel J H M; Korevaar, Erik W

OBJECTIVES: To demonstrate that novice dosimetry planners efficiently create clinically acceptable IMRT plans for head and neck cancer (HNC) patients using a commercially available multicriteria optimization (MCO) system. METHODS: Twenty HNC patients were enrolled in this in-silico comparative planning …

2015-04-12AlgemeenArtikel

Huidkanker na orgaantransplantatie : welke preventiemogelijkheden zijn er volgens de literatuur voor het voorkomen van maligne huidaandoeningen bij patiënten die een orgaantransplantatie ondergaan hebben?

Lisette Huussen; Mabitha Poort

Achtergrond: Patiënten die een orgaantransplantatie ondergaan hebben, zullen hun leven lang immunosuppressiva moeten slikken. Bij deze patiëntengroep ontwikkelen zich vaak maligne huidaandoeningen (NMSC), voornamelijk plaveiselcelcarcinomen. Doelstelling: De doelstelling van het onderzoek is het weergeven …

2013GezondheidBachelor

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