HBO Kennisbank

41 Resultaten

Sorteer op:

The influence of ROS1 fusion partners and resistance mechanisms in ROS1-TKI-treated non-small cell lung cancer patients

Zwierenga, Fenneke; Dijkhuizen, Christa (Biomolecules & Health); Korthuis, Patrick; Timens, Wim; Groen, Harry; Hiltermann, Jeroen; van den Berg, Anke; Drayer, Lyndsay; van der Wekken, Anthonie

Clinical outcomes in ROS1-fusion positive (ROS1+) non-small cell lung cancer (NSCLC) by fusion partner and resistance mechanisms are limited. This cohort study included 56 ROS1+ patients (FISH or NGS confirmed); fusion partners were identified in 27 cases, including CD74 (n = 10), EZR (n = 7), and SDC4 …

2025-08-29GezondheidArtikel

Effects of physical exercise during adjuvant chemotherapy for breast cancer on long-term tested and perceived cognition

Naaktgeboren, Willeke R.; Koevoets, Emmie W.; Stuiver, Martijn M. (Urban Vitality); van Harten, Wim H.; Aaronson, Neil K.; van der Wall, Elsken; Velthuis, Miranda; Sonke, Gabe; Schagen, Sanne B.; Groen, Wim G.; May, Anne M.

Purpose Cancer-related cognitive impairment (CRCI) following chemotherapy is commonly reported in breast cancer survivors, even years after treatment. Data from preclinical studies suggest that exercise during chemotherapy may prevent or diminish cognitive problems; however, clinical data are scarce. …

2024-05AlgemeenArtikel

Tailoring of exercise and dietary interventions to adverse effects and existing comorbidities in patients with ovarian cancer receiving chemotherapy

Stelten, Stephanie; ten Tusscher, Marieke R.; Stuiver, Martijn M. (Lectoraat Functioneel Herstel Bij Kanker); Hartman, Yvonne A.W.; van Lonkhuijzen, Luc R.C.W.; Kenter, Gemma G.; van der Leeden, Marike; Hoedjes, Meeke; Buffart, Laurien M.

Purpose: This study aims to capture the complex clinical reasoning process during tailoring of exercise and dietary interventions to adverse effects and comorbidities of patients with ovarian cancer receiving chemotherapy. Methods: Clinical vignettes were presented to expert physical therapists (n = …

2024AlgemeenArtikel

Effects of exercise during chemotherapy for breast cancer on long-term cardiovascular toxicity

Naaktgeboren, Willeke R.; Stuiver, Martijn M. (Lectoraat Functioneel Herstel Bij Kanker); Van Harten, Wim H.; Aaronson, Neil K.; Scott, Jessica M.; Sonke, Gabe; Van Der Wall, Elsken; Velthuis, Miranda; Leiner, Tim; Teske, Arco J.; May, Anne M.; Groen, Wim G.

Objective Animal data suggest that exercise during chemotherapy is cardioprotective, but clinical evidence to support this is limited. This study evaluated the effect of exercise during chemotherapy for breast cancer on long-term cardiovascular toxicity. Methods This is a follow-up study of two previously …

2023-10-30AlgemeenArtikel

Monitoring physical impact and recovery of pancreatic cancer treatment using consumer wearable health data

van der Schans, Cees P; van der Schans, Simon; van der Schans, Jurjen; Mylius, Caspar; Klaase, Joost

Consumer wearables health data may reflect the impact of pancreatic cancer and its treatment on cardiorespiratory fitness and the subsequent recovery after treatment. The patient is a 65-year-old male treated for borderline resectable pancreatic cancer. Treatment consisted of four courses of FOLFIRINOX …

2023-05-22AlgemeenArtikel

Effects of Exercise during Chemo- or Radiotherapy on Immune Markers

Anne de Hoop (Onderzoeker); Karin Valkenet (Onderzoeker); Jaap Dronkers (Onderzoeker); Cyrille Krul (Lector); Jelle Ruurda (Onderzoeker); Cindy Veenhof (Lector); Raymond Pieters (Lector)

Introduction: Patients with cancer receiving radio- or chemotherapy undergo many immunological stressors. Chronic regular exercise has been shown to positively influence the immune system in several populations, while exercise overload may have negative effects. Exercise is currently recommended for …

2023GezondheidArtikel

Effect of physical exercise on the hippocampus and global grey matter volume in breast cancer patients

Koevoets, E.W.; Geerlings, M.I.; Monninkhof, E.M.; Mandl, R.; Witlox, L.; van der Wall, E.; Stuiver, M.M. (Lectoraat Functioneel Herstel Bij Kanker); Sonke, G.S.; Velthuis, M.J.; Jobsen, J.J.; van der Palen, J.; Bos, M.E.M.M.; Göker, E.; Menke-Pluijmers, M.B.E.; Sommeijer, D.W.; May, A.M.; de Ruiter, M.B.; Schagen, S.B.

Background Physical exercise in cancer patients is a promising intervention to improve cognition and increase brain volume, including hippocampal volume. We investigated whether a 6-month exercise intervention primarily impacts total hippocampal volume and additionally hippocampal subfield volumes, cortical …

2023AlgemeenArtikel

Self-monitoring of physical activity after hospital discharge in patients who have undergone gastrointestinal or lung cancer surgery

de Leeuwerk, Marijke Elizabeth; Botjes, Martine; van Vliet, Vincent; Geleijn, Edwin; de Groot, Vincent; van Wegen, Erwin; van der Schaaf, Marike (Faculteit Gezondheid); Tuynman, Jurriaan; Dickhoff, Chris; van der Leeden, Marike

BACKGROUND: Self-monitoring of physical activity (PA) using an accelerometer is a promising intervention to stimulate PA after hospital discharge. OBJECTIVE: This study aimed to evaluate the feasibility of PA self-monitoring after discharge in patients who have undergone gastrointestinal or lung cancer …

2022-06-24AlgemeenArtikel

Physical Fitness and Chemotherapy Tolerance in Patients with Early-Stage Breast Cancer

Groen, Wim G.; Naaktgeboren, Willeke R.; van Harten, Wim H.; van Vulpen, Jonna K.; Kool, Nathalie (Faculteit Gezondheid); Sonke, Gabe S.; van der Wall, Elsken; Velthuis, Miranda J.; Aaronson, Neil K.; May, Anne M.; Stuiver, Martijn M. (Lectoraat Functioneel Herstel Bij Kanker)

INTRODUCTION: An optimal relative dose intensity (RDI) of adjuvant chemotherapy is associated with better survival in patients with breast cancer. Little is known about the role of physical fitness in attaining an adequate RDI in patients with early stage breast cancer. We investigated the association …

2022-04AlgemeenArtikel

Are active interventions effective compared to passive non-pharmacological interventions in the treatment of sensory and motor symptoms and improving quality of life in patients diagnosed with chemotherapyinduced peripheral neuropathy?

Susan Schnitter (Student); Caspar Mijlius (Begeleider)

Cancer was diagnosed in 19.292.789 patients worldwide in 2020, depending on the type of cancer treatment may involve chemotherapy. If a neurotoxic agent is used, patients can develop chemotherapy-induced peripheral neuropathy (CIPN) affecting 68% of patients within the first months of treatment. CIPN …

2021-04-17GezondheidBachelor

1 2 3 4 5

Over HBO Kennisbank