In de gezondheidszorg zijn datasets van klinische onderzoeken vaak hoogdimensionaal en hebben ze een kleine steekproefomvang, wat het risico op overfitting vergroot. Bovendien richt onderzoek in deze context zich doorgaans niet alleen op de nauwkeurigheid van de resulterende modellen, maar ook op de …

Samenvatting Behandelbeslissingen voor oudere oncologie patiënten zijn vaak complex. Dit komt door de grote variatie in achtergrond, comorbiditeiten, functionele capaciteiten en de impact van kankerbehandelingen op zowel de levenskwaliteit als de levensverwachting. In deze context is samen beslissen, …

BACKGROUND: Sarcopenic obesity (SO) is a clinical condition defined by the coexistence of high body fat mass and low muscle function and mass, which increases the risk of adverse health outcomes, including disability and mortality. Early detection and frequent monitoring of SO are essential for preventive …

Background&aims Obesity and sarcopenia are major health concerns, particularly among older populations. Dietary protein may help preserve muscle mass and function, but high-protein diets, especially from animal sources, may also increase adipose mass. We investigated associations of total, animal, and …

The widespread adoption of generative agents (GAs) is reshaping the healthcare landscape. Nonetheless, broad utilization is impeded by restricted access to high-quality, interoperable clinical documentation from electronic health records (EHRs) due to persistent legal, ethical, and technical barriers. …

Introduction: Mental health conditions are highly prevalent among adolescents, affecting one in seven individuals and accounting for 15% of the global disease burden in this age group. The promotion of health behaviours including physical activity, nutrition, and sleep, and reduction of sedentary behaviour, …

The European Union Artificial Intelligence (AI) Act was adopted in 2024 to protect public interests from AI-related harms. We aimed to determine whether the AI Act captures the most relevant stakeholders’ values for a high-risk AI Clinical Decision Support System (CDSS) for cardiovascular disease. Ethics …

Introduction High mechanical power is associated with mortality in patients who are critically ill and require invasive ventilation. It remains uncertain which components of mechanical power – volume, pressure or rate – increase mechanical power the most. Methods We conducted a post hoc analysis of a …

Background: Nutrition and nutritional care are essential for optimal outcomes, and, therefore of importance for patients with chronic limb threatening ischemia (CLTI) given their high risk of complications. However, insight is lacking in how healthcare professionals directly involved in the care of patients …

Background & aims: Accurate diagnosis of sarcopenia requires evaluation of muscle quality, which refers to the amount of fat infiltration in muscle tissue. In this study, we aim to investigate whether we can independently predict mortality risk in transcatheter aortic valve implantation (TAVI) patients, …