Samenvatting Behandelbeslissingen voor oudere oncologie patiënten zijn vaak complex. Dit komt door de grote variatie in achtergrond, comorbiditeiten, functionele capaciteiten en de impact van kankerbehandelingen op zowel de levenskwaliteit als de levensverwachting. In deze context is samen beslissen, …

BACKGROUND: Sarcopenic obesity (SO) is a clinical condition defined by the coexistence of high body fat mass and low muscle function and mass, which increases the risk of adverse health outcomes, including disability and mortality. Early detection and frequent monitoring of SO are essential for preventive …

Background&aims Obesity and sarcopenia are major health concerns, particularly among older populations. Dietary protein may help preserve muscle mass and function, but high-protein diets, especially from animal sources, may also increase adipose mass. We investigated associations of total, animal, and …

The widespread adoption of generative agents (GAs) is reshaping the healthcare landscape. Nonetheless, broad utilization is impeded by restricted access to high-quality, interoperable clinical documentation from electronic health records (EHRs) due to persistent legal, ethical, and technical barriers. …

The European Union Artificial Intelligence (AI) Act was adopted in 2024 to protect public interests from AI-related harms. We aimed to determine whether the AI Act captures the most relevant stakeholders’ values for a high-risk AI Clinical Decision Support System (CDSS) for cardiovascular disease. Ethics …

Introduction High mechanical power is associated with mortality in patients who are critically ill and require invasive ventilation. It remains uncertain which components of mechanical power – volume, pressure or rate – increase mechanical power the most. Methods We conducted a post hoc analysis of a …

Background: Nutrition and nutritional care are essential for optimal outcomes, and, therefore of importance for patients with chronic limb threatening ischemia (CLTI) given their high risk of complications. However, insight is lacking in how healthcare professionals directly involved in the care of patients …

Background & aims: Accurate diagnosis of sarcopenia requires evaluation of muscle quality, which refers to the amount of fat infiltration in muscle tissue. In this study, we aim to investigate whether we can independently predict mortality risk in transcatheter aortic valve implantation (TAVI) patients, …

Rationale: Sarcopenia and obesity are prevalent conditions and often co-occur within the same individual. ESPEN and EASO reached consensus on the definition of sarcopenic obesity (SO), encompassing altered muscle function (MF) and altered body composition (BC). However, both handgrip strength (HGS) and …

Background: Increasing life expectancy in high-income countries has been linked to a rise in fall mortality. In the Netherlands, mortality rates from falls have increased gradually from the 1950s, with some indication of stabilisation in the 1990s. For population health and clinical practice, it is important …