Although stressors are frequently linked to several negative health outcomes, experiencing stressors may be necessary for enhancing performance. At present, the literature is lacking a unified, comprehensive framework that accounts for both positive and negative outcomes following stressors. Therefore, …

New approach methodologies predicting human cardiotoxicity are of interest to support or even replace in vivo-based drug safety testing. The present study presents an in vitro–in silico approach to predict the effect of inter-individual and inter-ethnic kinetic variations in the cardiotoxicity of R- …

The present study compares two approaches to evaluate the effects of inter-individual differences in the biotransformation of chlorpyrifos (CPF) on the sensitivity towards in vivo red blood cell (RBC) acetylcholinesterase (AChE) inhibition and to calculate a chemical-specific adjustment factor (CSAF) …

Journal of Physics: Conference Series Paper • The following article is Open access Exploring the relationship between light and subjective alertness using personal lighting conditions J. van Duijnhoven1, M.P.J. Aarts1, E.R. van den Heuvel2 and H.S.M. Kort3,4 Published under licence by IOP Publishing …

Development of novel testing strategies to detect adverse human health effects is of interest to replace in vivo-based drug and chemical safety testing. The aim of the present study was to investigate whether physiologically based kinetic (PBK) modeling-facilitated conversion of in vitro toxicity data …

BACKGROUND & AIMS: Oral supplementation with vitamin D is recommended for older adults to maintain a sufficient 25-hydroxyvitamin D (25(OH)D) status throughout the year. While supplementation with vitamin D2 or D3 is most common, alternative treatment regimens exist which require further investigation …

The contribution of specific psychotropic drugs to fall risk in patients with dementia has not been quantified precisely until now. The authors evaluated the dose‐response relationship between psychotropic drugs and falls in nursing home residents with dementia. Daily drug use and daily falls were recorded …

WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT • Patients treated with selective serotonin re‐uptake inhibitors (SSRIs) have been shown to have an increased risk of falling. In nursing homes, many patients with dementia are given SSRIs as a treatment for depression. In this group, however, the possible risk …

Falls are a major health problem in nursing home residents with dementia. In nursing homes one-third of all falls results in an injury. In order to take tailor-made preventive measures in time, the fall risk profile of each individual nursing home resident should be periodically evaluated. A systematic …