Polyhydroxyalkanoates (PHAs) are biodegradable biopolymers (polyesters), produced by a wide range of bacterial strains. They are gaining increasing interest in different research fields, due to their sustainability and environmental-friendly properties. Additionally, PHAs are also biocompatible, which …

İnsan vücudu ile elektromanyetik dalgaların etkileşimi, dokuların ve hücrelerin dielektrik özellikleri gibi faktörlerin yanı sıra diğer etkenler tarafından da şekillenir. Mikrodalga hipertermi ve mikrodalga görüntüleme uygulamalarında, deney ortamı ölçüm düzeneklerinde simülasyon sonuçlarını doğrulamak …

Background: Adverse outcome pathway (AOP) networks are versatile tools in toxicology and risk assessment that capture and visualize mechanisms driving toxicity originating from various data sources. They share a common structure consisting of a set of molecular initiating events and key events, connected …

RATIONALE: To date, causal therapy is potentially available for GRIN2B-related neurodevelopmental disorder (NDD) due to loss-of-function (LoF) variants in GRIN2B, resulting in dysfunction of the GluN2B subunit-containing N-methyl-d-aspartate receptor (NMDAR). Recently, in vitro experiments showed that …

New approach methodologies predicting human cardiotoxicity are of interest to support or even replace in vivo-based drug safety testing. The present study presents an in vitro–in silico approach to predict the effect of inter-individual and inter-ethnic kinetic variations in the cardiotoxicity of R- …

De toenemende bacterieresistentie tegen antibiotica bij de mens èn in de aquacultuur vraagt om alternatieven. Op de HAS Hogeschool is, in samenwerking met de Wageningen Universiteit en NGN Products, via in vitro studies getest of essentiële oliën een remmend effect hebben op de groei van twee veelvoorkomende …

For almost fifteen years, the availability and regulatory acceptance of new approach methodologies (NAMs) to assess the absorption, distribution, metabolism and excretion (ADME/biokinetics) in chemical risk evaluations are a bottleneck. To enhance the field, a team …

Development of novel testing strategies to detect adverse human health effects is of interest to replace in vivo-based drug and chemical safety testing. The aim of the present study was to investigate whether physiologically based kinetic (PBK) modeling-facilitated conversion of in vitro toxicity data …

The concept of green biorefinery is based on the processing of green biomass into range of innovative products. The basic idea is to use the green biomass in the most optimal way to produce energy and marketable products. Grass silage has versatile properties as raw material for green biorefinery with …

The aim of the present study was to predict the effect of inter-individual and inter-ethnic human kinetic variation on the sensitivity towards acute liver toxicity of lasiocarpine in the Chinese and the Caucasian population, and to derive chemical specific adjustment factors (CSAFs) by integrating variation …