Over the period February 2023 to July 2023, the aim was to develop a method for the determination of endotoxin in pharmaceutical products according to GMP rules. To bring this research to a successful conclusion, the intention was to demonstrate endotoxins in pharmaceutical products using the Kinetic …

Sodium-glucose co-transporter 2 (SGLT2) inhibitors, including canagliflozin, reduce the risk of cardiovascular and kidney outcomes in patients with and without type 2 diabetes, albeit with a large interindividual variation. The underlying mechanisms for this variation in response might be attributed …

Background The gait modification strategies Trunk Lean and Medial Thrust have been shown to reduce the external knee adduction moment (EKAM) in patients with knee osteoarthritis which could contribute to reduced progression of the disease. Which strategy is most optimal differs between individuals, but …

Het belang bij kinematische analyses in de sport neemt toe dankzij technologische ontwikkelingen en meetapparatuur. Het bedrijf Kinetic Analysis in Breda richt zich op het analyseren van bewegingen met behulp van deze apparatuur. In2017 ontwikkelde KA een kinematisch analysetool voor het Nederlands hockeyteam. …

Kinetic Analysis B.V. voert uitgebreide bewegingsanalyses uit bij atleten uit verschillende sporten zoals, atletiek en hockey. Deze analyses worden gedaan aan de hand van inertial measurement units (IMU’s), hierdoor kan de bewegingsuitslag van gewrichten van een atleet gemeten worden. Door dit in kaart …

New approach methodologies predicting human cardiotoxicity are of interest to support or even replace in vivo-based drug safety testing. The present study presents an in vitro–in silico approach to predict the effect of inter-individual and inter-ethnic kinetic variations in the cardiotoxicity of R- …

The present study compares two approaches to evaluate the effects of inter-individual differences in the biotransformation of chlorpyrifos (CPF) on the sensitivity towards in vivo red blood cell (RBC) acetylcholinesterase (AChE) inhibition and to calculate a chemical-specific adjustment factor (CSAF) …

Hamstringblessures ontstaan veel tijdens maximaal sprinten en niet tijdens submaximaal sprinten, dit kan verschillende oorzaken hebben. Er wordt gedacht dat een van die oorzaken de kanteling van het bekken is in het sagittale vlak, omdat de kanteling van het bekken een rol speelt in de lengte van de …

There are three volumes in this body of work. In volume one, we lay the foundation for a general theory of organizing. We propose that organizing is a continuous process of ongoing mutual or reciprocal influence between objects (e.g., human actors) in a field, whereby a field is infinite and connects …

Energy usage is a fundamental property of injection molding machines. The development of these machines is accompanied by two contradictory objectives. On the one hand, a producer wants to produce as quickly as possible, cycle times must be as short as possible, and the number of products produced simultaneously …