Designing lead-free piezoelectric ceramics with tailored electrical properties remains a critical challenge for various applications. In this paper we present a novel methodology integrating Machine Learning (ML) and optimization procedures to fine-tune electrical properties in lead-free (1-x) Na0.5 …

This paper presents user-friendly code for the implementation of a loss function for neural network time series models that exploits the topological structures of financial data. By leveraging the recently-discovered presence of topological features present in financial time series data, the code offers …

Klimaatadaptatie bevindt zich in een fase van implementatie en versnelling, wat terug te zien is in de snelle verspreiding van maatregelen voor stedelijk water- en hittebeheer in steden over de hele wereld. Met name op natuur gebaseerde oplossingen ('nature-based solutions' of NBS) zijn recentelijk in …

Tumor necrosis factor alpha (TNF-α) and its key role in modulating immune responses has been widely recognized as a therapeutic target for inflammatory and neurodegenerative diseases. Even though inhibition of TNF-α is beneficial for the treatment of certain inflammatory diseases, total neutralization …

5% to 10% of all cancers are linked to gene mutations inherited from parents. The most common gene related to hereditary cancer is the p53 gene. It is a crucial tumor suppressor. However, the mutated gene is commonly inherited from one generation to another one. The functions of p53 resume to the activation …

This thesis is a part of BEESPOKE, an international initiative to reverse the decline of wild pollinators and create more resilient agroecosystems by providing expertise, tools and financial knowledge to land managers and policy makers. The severe decline of pollinators and other beneficial insects is …

It is estimated that over 30,000 lesions in the DNA are generated per cell per day. In S-phase, lesions in the DNA can stall replication, which can lead to secondary lesions such as DNA double- strand breaks. The DNA damage tolerance (DDT) network enables replication to be continued in the presence of …

BACKGROUND: People with Alzheimer's disease (AD) experience, in addition to the progressive loss of cognitive functions, a decline in functional performance such as mobility impairment and disability in activities of daily living (ADL). Functional decline in dementia is mainly linked to the progressive …

The Hogeschool Utrecht Centre of Technology and Innovation is currently researching various applications of multi-agent technology (MAS). This research considers the posibilities of developing an agent-based system capable of monitoring vital functions and making predictions on a patient’s health to …

Assessment of the seismic vulnerability of the building stock in the earthquake-prone Marmara region of Turkey is of growing importance since such information is needed for reliable estimation of the losses that possible future earthquakes are likely to induce. The outcome of such loss assessment exercises …