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L2026M+G2032R variant confers resistance to ROS1 tyrosine kinase inhibitors in SCL34A2-ROS1 overexpressing Ba/F3 cells through a reduced ATP binding pocket volume

Dijkhuizen, Christa (Biomolecules & Health); Korthuis, Patrick; Vilachã, Juliana F.; Smelt, Maaike; van der Wekken, Anthonie; van den Berg, Anke; Drayer, Lyndsay

Background The ROS1 G2032R mutation is the most common on-target resistance mutation in crizotinib treated ROS1-positive lung cancer patients. The aim of our study was to investigate resistance mechanisms in SCL34A2-ROS1G2032R positive Ba/F3 cells against second line treatment with lorlatinib. Methods …

2023-10-21GezondheidConferentiebijdrage

Using anthocyanin produce tons as a visual marker for CRISPR/Cas9 mutagenesis in Petunia

Milan Plasmeijer (Onderzoeker); Paulus den Hollander (Onderzoeker); Nelleke Kreike (Lector)

Using anthocyanin produce tons as a visual marker for CRISPR/Cas9 mutagenesis in Petunia

2017-11-01Natuur & LandbouwConferentiebijdrage

Student driven CRISPR/Cas9 mutagenesis in Petunia

Paulus den Hollander (Onderzoeker); Milan Plasmeijer (Onderzoeker); Nelleke Kreike (Lector)

Student driven CRISPR/Cas9 mutagenesis in Petunia

2017-11-01Natuur & LandbouwConferentiebijdrage

Genome-wide analysis of bacterial determinants of plant growth promotion and induces systemic resistance by Pseudomonas fluorescens

Cheng, X.; Etalo, D.W.; Mortel, J.E. van de

Pseudomonas fluorescens strain SS101 (Pf.SS101) promotes growth of Arabidopsis thaliana, enhances greening and lateral root formation, and induces systemic resistance (ISR) against the bacterial pathogen Pseudomonas syringae pv. tomato (Pst). Here, targeted and untargeted approaches were adopted to identify …

2017-09-11Natuur & LandbouwArtikel

Targeted mutagenesis of CCoAOMT1 in Petunia using CRISPR/Cas 9 Technology

Beau Wagemaker (Student); Milan Plasmeijer (Onderzoeker); Paulus den Hollander (Onderzoeker); Nelleke Kreike (Lector)

Targeted mutagenesis of CCoAOMT1 in Petunia using CRISPR/Cas 9 Technology

2017-03-23Natuur & LandbouwConferentiebijdrage

Site directed mutagenesis in Petunia using CRISPR/CAS9 technology

Paulus den Hollander (Onderzoeker); Nelleke Kreike (Lector)

The Green Biotechnology research group focusses on the application of molecular breeding/biotechnological tools and also on the development/analysis of new tools, for the breeding of enhanced vegetable crops and ornamental plants. The research group is positioned within Inholland University of Applied …

2013-01-01Natuur & LandbouwConferentiebijdrage

ss-TEA

umc, radboud; Fleuren, Wilco W M; Verhoeven, Stefan; van den Beld, Sven; Alkema, Wynand; de Vlieg, Jacob; Klomp, Jan P G

Background: G-protein coupled receptors (GPCRs) are involved in many different physiological processes and their function can be modulated by small molecules which bind in the transmembrane (TM) domain. Because of their structural and sequence conservation, the TM domains are often used in bioinformatics …

2011-08-10AlgemeenArtikel

Saturation mutagenesis reveals the importance of residues alphaR145 and alphaF146 of penicillin acylase in the synthesis of beta-lactam antibiotics

Jager, Simon A W; Shapovalova, Irina V; Jekel, Peter A; Alkema, Wynand B L; Svedas, Vytas K; Janssen, Dick B

Penicillin acylase (PA) from Escherichia coli can catalyze the coupling of an acyl group to penicillin- and cephalosporin-derived beta-lactam nuclei, a conversion that can be used for the industrial synthesis of beta-lactam antibiotics. The modest synthetic properties of the wild-type enzyme make it …

2008-01-01AlgemeenArtikel

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