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New homocysteine consumption assay for high-throughput screening of human cystathionine-β-synthase

Nakládal, Dalibor; Oerlemans, Rick; Molitorisová, Miroslava; Chomaničová, Nikola; Zorkócy, Gabriel; Yoseif, Christina; van der Graaf, Adrianus Cornelis; Stuchlík, Stanislav; Krenning, Guido; Groves, Matthew R.; Heeres, André (Biobased Chemistry & Refinery); Levarski, Zdenko; Kyselovič, Ján; Henning, Rob H.; Deelman, Leo E.

Hyperhomocysteinemia is a risk factor for cardiovascular disease, neurological disorders, and bone abnormalities. The key enzyme in homocysteine metabolism, cystathionine-β-synthase (CBS) is recognized as a target for new homocysteine-lowering therapies including enzyme replacement and gene therapy. …

2025-04-11Techniek; …Artikel

Promoting physical activity during retirement age with psychological components

Collazo-Castiñeira, Paula; Echegoyen, Ignacio; Schoufour, Josje (Lectoraat Voeding En Beweging); Álvarez-Díaz, Noelia; Botella, Juan; Janiszewska, Katarzyna; Jiménez-Domínguez, Cristina; Lavilla, Vicente; López-Iglesias, Ana; Mejía Ramírez-Arellano, Manuel V.; Tsagari, Amalia; Verwijs, Marije H.; Cruz-Jentoft, Alfonso J.; Sánchez-Izquierdo, Macarena

Background: Introduction: Physical activity is essential in preventing and treating age-related chronic diseases and mortality. Retirement is a key period to promote health behaviours, as individuals restructure their routines. Thus, we aimed to identify effective components and behaviour change techniques …

2025AlgemeenAndersoortig materiaal

Nutritional risk screening

Jager-Wittenaar, Harriët (Malnutrition And Healthy Ageing); Sealy, Martine (Malnutrition And Healthy Ageing); Naumann, Elke; de van der Schueren, Marian

PURPOSE OF REVIEW: With the shifts in society, healthcare and the profile of the malnourished individual, a re-consideration of the goal of nutritional risk screening is needed: screening for malnutrition, or screening for risk of malnutrition? In this review article, we reflect on the role of nutritional …

2024-06-06Gezondheid; …Artikel

Pre-Participation Screenings Frequently Miss Occult Cardiovascular Conditions in Apparently Healthy Male Middle-Aged First-Time Marathon Runners

Laily, Inarota; Wiggers, Tom G.H.; Van Steijn, Niels; Bijsterveld, Nick; Bakermans, Adrianus J.; Froeling, Martijn; Van Den Berg-Faay, Sandra; De Haan, Ferdinand H. (Urban Vitality); De Bruin-Bon, Rianne H.A.C.M.; Boekholdt, S. Matthijs; Planken, R. Nils; Verhagen, Evert; Jorstad, Harald T.

Introduction: The optimal pre-participation screening strategy to identify athletes at risk for exercise-induced cardiovascular events is unknown. We therefore aimed to compare the American College of Sports Medicine (ACSM) and European Society of Cardiology (ESC) pre-participation screening strategies …

2024-06AlgemeenArtikel

The SAFE procedure: a practical stopping heuristic for active learning-based screening in systematic reviews and meta-analyses

Josien Boetje (Onderzoeker); Rens van de Schoot

Active learning has become an increasingly popular method for screening large amounts of data in systematic reviews and meta-analyses. The active learning process continually improves its predictions on the remaining unlabeled records, with the goal of identifying all relevant records as early as possible. …

2024ICT & Media; …Artikel

The SAFE procedure: a practical stopping heuristic for active learning‑based screening in systematic reviews and meta‑analyses

Josien Boetje (Onderzoeker); Rens van de Schoot

2024ICT & MediaArtikel

Malnutrition screening tools are not sensitive enough to identify older hospital patients with malnutrition

van Dronkelaar, Carliene (Lectoraat Voeding En Beweging); Tieland, Michael (Lectoraat Voeding En Beweging); Cederholm, Tommy; Reijnierse, Esmee M. (Lectoraat Voeding En Beweging); Weijs, Peter J. M. (Lectoraat Voeding En Beweging); Kruizenga, Hinke

This study evaluates the concurrent validity of five malnutrition screening tools to identify older hospitalized patients against the Global Leadership Initiative on Malnutrition (GLIM) diagnostic criteria as limited evidence is available. The screening tools Short Nutritional Assessment Questionnaire …

2023-12-17AlgemeenArtikel

What If the Clinical and Older Adults’ Perspectives about Frailty Converge? A Call for a Mixed Conceptual Model of Frailty

Asya Hani Khalil; Robbert Gobbens (Lector)

Abstract: Existing frailty models have enhanced research and practice; however, none of the models accounts for the perspective of older adults upon defining and operationalizing frailty. We aim to propose a mixed conceptual model that builds on the integral model while accounting for older adults’ perceptions …

2023-12-15GezondheidArtikel

Hereditary cancer

Femke Christenhusz (Student)

Hereditary Breast and Ovarian Cancer (HBOC) typically arises from mutations inherited in the germline. BRCA1 and BRCA2 mutaions are predominant contributors to HBOC, accounting for the majority of cases. These mutations are associated with 10% of ovarian cancer cases and 3-5% of breast cancer cases [4]. BRCA1 …

2023-12-12Gezondheid; …Bachelor

The nurse-led GILL eHealth intervention for improving physical health and lifestyle behaviours in clients with severe mental illness

Meike Hoogervorst (Lid Lectoraat); Berno van Meijel (Lector); Esther Krijnen-de Bruin (Lid Lectoraat); Aartjan Beekman; Nynke Boonstra; Marcel C. Adriaanse

Abstract Background Clients with severe mental illness (SMI) have overall poor physical health. SMI reduces life expectancy by 5–17 years, primarily due to physical comorbidity linked to cardiometabolic risks that are mainly driven by unhealthy lifestyle behaviours. To improve physical health in clients …

2023-09-18GezondheidArtikel

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