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Mitochondrial dysfunction in human hypertrophic cardiomyopathy is linked to cardiomyocyte architecture disruption and corrected by improving NADH-driven mitochondrial respiration

Nollet, Edgar E; Duursma, Inez; Rozenbaum, Anastasiya; Eggelbusch, Moritz; Wüst, Rob C I; Schoonvelde, Stephan A C; Michels, Michelle; Jansen, Mark; van der Wel, Nicole N; Bedi, Kenneth C Jr; Margulies, Kenneth B; Nirschl, Jeff; Kuster, Diederik W D; van der Velden, Jolanda

Aims Genetic hypertrophic cardiomyopathy (HCM) is caused by mutations in sarcomere protein-encoding genes (i.e. genotype-positive HCM). In an increasing number of patients, HCM occurs in the absence of a mutation (i.e. genotype-negative HCM). Mitochondrial dysfunction is thought to be a key driver of …

2023-04-01AlgemeenArtikel

Right ventricular load and function during exercise in patients with open and closed atrial septal defect type secundum

Pieter De Meester; Roselien Buys; Werner Budts; Marion Delcroix; Luc Vanhees (Lector); Jens-Uwe Voigt; Alexander Van de Bruaene

Abstract Purpose: This study aimed at evaluating (1) right ventricular (RV) mean power during exercise, (2) the contribution of flow and pressure to RV mean power, and (3) the impact of pulmonary artery pressure on RV function during exercise. Methods: Fifty patients with atrial septal defect (ASD) …

2013GezondheidArtikel

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Mitochondrial dysfunction in human hypertrophic cardiomyopathy is linked to cardiomyocyte architecture disruption and corrected by improving NADH-driven mitochondrial respiration

Right ventricular load and function during exercise in patients with open and closed atrial septal defect type secundum

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