Objectives To assess the impact of BCG vaccination on systemic inflammation in neonates, focusing on sex-specific differences and the relationship between circulating inflammatory proteins and immune responses, including cytokine production and antibody levels. Methods A randomized clinical trial was …

Some individuals, even when heavily exposed to an infectious tuberculosis patient, do not develop a specific T-cell response as measured by interferon-gamma release assay (IGRA). This could be explained by an IFN-γ-independent adaptive immune response, or an effective innate host response clearing Mycobacterium …