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Investigating the role of AMPK-mediated TET2 in diabetes-induced myelopoiesis and the effect of Vitamin C on restoring TET2 function.

research report

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Investigating the role of AMPK-mediated TET2 in diabetes-induced myelopoiesis and the effect of Vitamin C on restoring TET2 function.

research report

Rechten: Alle rechten voorbehouden

Samenvatting

Diabetes remains a major risk for atherosclerotic-cardiovascular disease (CVD). While many mechanisms have been explored, the full extent of how diabetes promotes CVD remains unknown. An emerging area in diabetes is the influence of epigenetic regulation of gene expression. Diabetes has been shown to deactivate an important enzyme known as TET2 in hematopoietic stem cells (HSPCs), which is responsible for stabilizing gene expression through promoting 5‐cytosine hydroxymethylation (5-hmC). Our group has recently found in unpublished data that diabetes suppresses TET2 activity via the reduction of AMPK phosphorylation, subsequently decreasing 5-hmC in HSPCs in the bone marrow.

OrganisatieHogeschool van Arnhem en Nijmegen
AfdelingAcademie Toegepaste Biowetenschappen en Chemie
PartnerBaker Heart and Diabetes Institute
Datum2023-03-15
TypeBachelor
TaalEngels

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