Clinical outcomes in ROS1-fusion positive (ROS1+) non-small cell lung cancer (NSCLC) by fusion partner and resistance mechanisms are limited. This cohort study included 56 ROS1+ patients (FISH or NGS confirmed); fusion partners were identified in 27 cases, including CD74 (n = 10), EZR (n = 7), and SDC4 …

Multi-layer cell constructs produced in vitro are an innovative treatment option to support the growing demand for therapy in regenerative medicine. Our research introduces a novel construct integrating organ-derived decellularised extracellular matrix (dECM) hydrogels and 3D-printed biodegradable polymer …

Since 2012, the harbor seal (Phoca vitulina) population in the Dutch Wadden Sea has been in decline, raising concerns about the potential role of infectious diseases. Historical outbreaks like those caused by Phocine Distemper Virus (PDV) and Influenza A virus subtype H10N7, have shown that pathogens …

SMEs often operate with limited technical expertise and constrained budgets, making it difficult to implement comprehensive cybersecurity measures. Yet, these businesses play a critical role in the Dutch economy, employing over 70% of the working population and contributing €309 billion annually. Ensuring …

Onder- en overvoeding op Intensive Care-afdelingen (IC's) wordt in verband gebracht met een langere ziekenhuisopname, een verhoogde morbiditeit en een verhoogde mortaliteit, en een verhoogde mortaliteit. Deze studie onderzoekt of IC-patiënten optimaal gevoed werden volgens de European Society voor Klinische …

Chapter 1: General introduction. A specific group of people with disabilities includes individuals with profound intellectual and multiple disabilities (PIMD). However, individuals with PIMD form a heterogeneous group regarding the origins of their underlying conditions leading to profound disabilities …

Purpose: To our knowledge, there have been no comparative studies evaluating the associations of frailty defined using the Tilburg Frailty Indicator (TFI), frailty phenotype by Fried et al, and FRAIL scale with all-cause mortality in Turkiye. In this study, we aimed to evaluate the ability of these instruments …

Shellfish are a healthy source of protein but more strict regulation for traditional shellfish fisheries and fluctuations in population size warrant a need for sustainable and more reliable alternatives. These alternatives can be, for example, the culturing of new species like hard clam (Mercenaria mercenaria). …

Background: Frailty is a common condition in older people, and its prevalence increases with age. With an ageing population, the adverse consequences of frailty cause an increasing appeal to the health care system. The impact of frailty on population level is often assessed using adverse health outcomes, …

Arthropod pests cause signifcant problems in agricultural crops all around the world. As chemical pesticide use becomes less desired, there is a need for alternative methods of pest control. Inspired by the natural adhesiveness of arthropod trapping plants, we examined the efectiveness of adhesive droplets …