Brain disorders, such as Alzheimer’s disease and epilepsy have been linked to an imbalance in excitatory and inhibitory (E/I) inputs in the brain. However, the molecular mechanisms underlying E/I balance and plasticity in the brain are largely unresolved. Inhibitory synapses have a strong impact on brain …

This study provides insights into novel combinations of hydrothermal modifications and mineral enrichment by demonstrating the versatility of this environmentally more benign approach compared to other common chemical starch modifications like crosslinking. Heat-moisture treatment (HMT) (15% moisture, …

Knowledge on the biodiversity and abundance of phytoplankton is key for many ecological and societal (e.g., blue growth) questions. Gathering temporal variation and spatial patterns on key indicators requires reliable and standardized protocols on sampling, species identification and counting. Numerous …

Objectives: Pulmonary hypertension is one of the leading causes of death in systemic sclerosis. Early detection and treatment of pulmonary hypertension in systemic sclerosis is crucial. Nailfold capillaroscopy microscopy, vascular autoantibodies AT1R and ETAR, and several candidate-biomarkers have the …

Aims Genetic hypertrophic cardiomyopathy (HCM) is caused by mutations in sarcomere protein-encoding genes (i.e. genotype-positive HCM). In an increasing number of patients, HCM occurs in the absence of a mutation (i.e. genotype-negative HCM). Mitochondrial dysfunction is thought to be a key driver of …

SMPD4 is a neutral sphingomyelinase that plays an important role in sphingolipid metabolism. Sphingolipids are a family of lipid molecules abundantly present in the brain where they play an important role in the brain development and function due to their essential cellular role as structural components …

A main challenge in single emitter microscopy is that it is difficult to efficiently collect all the emitted light from single photon sources. Due to the dipole nature of the single photon sources, is it hard to measure the brightness of these molecules in a calibrated manner, since the light is not …

We developed a dedicated Atomic Force Microscopy set-up in a hermetically closed environment, coupled with a Galvanostat/Potentiostat which will be able to perform in-situ and operando measurements at the cathode-electrolyte and anode-electrolyte interface to monitor the interphase processes. The setup …

This study aimed to get more insight into the spatial distribution pattern of the macrobenthos at the Vlakte van de Raan in relation to environmental gradients (median grain size, salinity and bathymetry). 82 samples were collected in November 2016 with a Van Veen grab using the research vessel the ‘RV …

The performance of neural electrodes in physiological fluid, especially in chronic use, is critical for the success of functional electrical stimulation devices. Tips of the Utah electrode arrays (UEAs) were coated with sputtered iridium oxide film (SIROF) and activated iridium oxide film (AIROF) to …