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Stratified exercise therapy compared with usual care by physical therapists in patients with knee osteoarthritis: A randomized controlled trial protocol (OCTOPuS study).

J. Knoop; J Dekker; M van der Leeden; M. de Rooij; W.F. Peter; L. van Bodegom-Vos; J.M. van Dongen; N. Lopuhäa; K.L. Bennell; W.F. Lems; M. van der Esch; T.P. Vliet Vlieland; R.W.J.G. Ostelo

OBJECTIVES: Knee osteoarthritis (OA) is characterized by its heterogeneity, with large differences in clinical characteristics between patients. Therefore, a stratified approach to exercise therapy, whereby patients are allocated to homogeneous subgroups and receive a stratified, subgroup-specific intervention, …

2020AlgemeenArtikel

Stratified exercise therapy compared with usual care by physical therapists in patients with knee osteoarthritis

Knoop, Jesper; Dekker, Joost; van der Leeden, Marike; de Rooij, Mariëtte; Peter, Wilfred F. H.; van Bodegom-Vos, Leti; van Dongen, Johanna M; Lopuhäa, Nique; Bennell, Kim L.; Lems, Willem F.; van der Esch, Martin (Urban Vitality); Vliet Vlieland, Thea P.M.; Ostelo, Raymond W.J.G.

2020AlgemeenArtikel

Cost-effectiveness of a lifestyle intervention for people with a serious mental illness (SMILE)

Florine Walburg (Lid Lectoraat); Berno van Meijel (Lector); M.W. van Tulder; M.C. Adriaanse

Abstract Background: Cardiovascular disease is the leading cause of the estimated 11–25 years reduced life expectancy for persons with serious mental illness (SMI). This excess cardiovascular mortality is primarily attributable to obesity, diabetes, hypertension, and dyslipidaemia. Obesity is associated …

2019GezondheidArtikel

The PRECIS-2 tool has good interrater reliability and modest discriminant validity

Loudon, Kirsty; Zwarenstein, Merrick; Sullivan, Frank; Donnan, Peter; Gágyor, Ildikó; Hobbelen, Hans (Ageing And Allied Health Care); Althabe, Fernando; Krishnan, Jerry A; Treweek, Shaun

OBJECTIVE: PRECIS - 2 is a tool that could improve design insight for trialists. Our aim was to validate the PRECIS - 2 tool, unlike its predecessor, testing the discriminant validity and inter-rater reliability. STUDY DESIGN AND SETTING: Over 80 international trialists, methodologists, clinicians and …

2017-06-08Gezondheid; …Artikel

HELP! Problems in executing a pragmatic, randomized, stepped wedge trial on the Hospital Elder Life Program to prevent delirium in older patients

Noor Heim; Henk F. van Stel; Roelof Ettema (Lid Lectoraat); Roos C. van der Mast; Sharon K. Inouye; Marieke Schuurmans (Lector)

Background: A pragmatic, stepped wedge trial design can be an appealing design to evaluate complex interventions in real-life settings. However, there are certain pitfalls that need to be considered. This paper reports on the experiences and lessons learned from the conduct of a cluster randomized, …

2017GezondheidArtikel

Stop or Go? Preventive cognitive therapy with guided tapering of antidepressants during pregnancy: study protocol of a pragmatic multicentre non-inferiority randomized controlled trial

H. Burger; N.M. Molenaar; H.W. Torij (Lector); G.J. Bonsel; M.P. Lambregtse - van den Berg; W.J.G. Hoogendijk; M.E. Brouwer; C.L.H. Bockting; J.J. Duvekot; C.N. van der Veere

Approximately 6.2% of women in the USA and 3.7% of women in the UK, use Selective Serotonin Reuptake Inhibitors (SSRIs) during their pregnancies because of depression and/or anxiety. In the Netherlands, this prevalence is around 2%. Nonetheless, SSRI use during pregnancy is still controversial. On the …

2016-01-01GezondheidArtikel

Collaborative care for patients with bipolar disorder

T.Y.G. (Nienke) van der Voort (Lid Lectoraat)

This thesis provides a report on research aimed at enhancing treatment of patients with bipolar disorder. We describe various aspects of treatment of bipolar disorder. The central study reported in this thesis is an effect study of a multicomponent intervention, Collaborative Care. Chapter 1 describes …

2015-05-27GezondheidProefschrift

The CareWell-primary care program: design of a cluster controlled trial and process evaluation of a complex intervention targeting community-dwelling frail elderly

F.G.H. Ruikes; ARM Meys; G. van de Wetering; R.P. Akkermans; Betsie van Gaal; S.U. Zuidema; H.J. Schers; Theo van Achterberg; R.T.C.M. Koopmans

Background: With increasing age and longevity, the rising number of frail elders with complex and numerous health-related needs demands a coordinated health care delivery system integrating cure, care and welfare. Studies on the effectiveness of such comprehensive chronic care models targeting frail …

2012AlgemeenArtikel

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