Atrial fibrillation (AF) is the most common clinical tachyarrhythmia associated with significant morbidity and mortality and is expected to affect approximately 30 million North Americans and Europeans by 2050. AF is a persistent disease, caused by progressive, often age-related, derailment of proteostasis …

Dysphagia is reported in advanced stages of Duchenne muscular dystrophy (DMD). The population of DMD is changing due to an increasing survival. We aimed to describe the dysphagia in consecutive stages and to assess the underlying mechanisms of dysphagia in DMD, in order to develop mechanism based recommendations …

2.1 Background and Objective This research explores the Housemothers' vision on care at the Assessment Center of World Hope International, where they provide aftercare for victims of sexual abuse and exploitation. World Hope International, a Christian relief and development organization (founded in the …

Tijdens muziektherapie kiezen veel jongeren tussen 12-18 jaar er graag voor om te zingen of te rappen. Het komt regelmatig voor dat zij hierbij andersoortig stemgebruik hanteren dan hun eigen, natuurlijke stem. Met name wanneer ze sociaal-emotionele problemen hebben of een psychiatrische stoornis. Om …

From an evidence-based perspective, cardiopulmonary exercise testing (CPX) is a well-supported assessment technique in both the United States (US) and Europe. The combination of standard exercise testing (ET) (ie, progressive exercise provocation in association with serial electrocardiograms [ECG], hemodynamics, …

From an evidence-based perspective, cardiopulmonary exercise testing (CPX) is a well-supported assessment technique in both the United States (US) and Europe. The combination of standard exercise testing (ET) [i.e. progressive exercise provocation in association with serial electrocardiograms (ECGs), …

This dissertation explores the controversial concept of the green economy and the rapidly increasing environmental concerns associated to the heavy energy industry. The main objective of this paper is to investigate how China's 12th Five-Year Plan responds to the green economy paradigm. Hence, it examines …

Fuel cell hybrid power trains comprise an energy storage to supply peaks in the power demand and to facilitate regenerative braking. In terms of control systems, the presence of storage provides additional freedom to minimize the vehicle’s fuel consumption. In a previous paper [1] an analytical solution …

Glucocorticoids (GCs), such as prednisolone (PRED), are widely prescribed anti-inflammatory drugs, but their use may induce glucose intolerance and diabetes. GC-induced beta cell dysfunction contributes to these diabetogenic effects through mechanisms that remain to be elucidated. In this study, we hypothesized …

BACKGROUND: Prednisolone and other glucocorticoids (GCs) are potent anti-inflammatory and immunosuppressive drugs. However, prolonged use at a medium or high dose is hampered by side effects of which the metabolic side effects are most evident. Relatively little is known about their effect on gene-expression …