Protein kinases function as pivotal regulators in biological events, governing essential cellular processes through the transfer of phosphate groups from ATP molecules to substrates. Dysregulation of kinase activity is frequently associated with cancer, ocasionally arising from chromosomal translocation …

Owing to the non-toxic, nonimmunogenic effects and high affinity to specific molecules, some single-stranded oligonucleotides, namely aptamers, can be exploited in biochemical applications to deliver bioactive elements and interact with the desired targets. Among many identified aptamers, D#7 was utilized …

This literature review will focus on how CRISPR/Cas can be used in curing diabetes. CRISPR is a newly discovered genetical engineering tool that was first found in bacteria and it has an important immune function, protecting them from viral infections by cutting the viral DNA, thereby disabling it. Researchers …

The purpose of this research is to validate and optimize the synthesis of the natively linked α-UbADPr & β-UbADPr (19α,β) on arginine 42 to further study in the enzymes of Legionella Pneumophilia. In the synthesis of UbADPr the sub goal was to synthesize as much as possible of two molecules (building …

SMPD4 is a neutral sphingomyelinase that plays an important role in sphingolipid metabolism. Sphingolipids are a family of lipid molecules abundantly present in the brain where they play an important role in the brain development and function due to their essential cellular role as structural components …

The coronavirus disease-19 (COVID-19) pandemic still poses serious threats to global public health. Therefore, the scientific community is desperately looking for suitable vaccines and pharmacological treatment options. This thesis completes the internship at Specs Compound Handling BV and describes …

Perfluoro alkyl substances (PFAS) are substances in which contain multiple fluorine atoms. The fluorine atoms are bound to, often, long carbon chains. PFAS are able to repel dirt and water, due to the large amount of fluorine atoms in the molecules. PFAS are also chemically and thermally stable. Many …

Early links in the food web are crucial to sustain higher levels in the food web. Molecules of high importance, for example unsaturated fatty acids, play a key role in aquatic ecosystems. Unsaturated fatty acids are produced by primary producers for instance phytoplankton. Almost all organisms need to …

A main challenge in single emitter microscopy is that it is difficult to efficiently collect all the emitted light from single photon sources. Due to the dipole nature of the single photon sources, is it hard to measure the brightness of these molecules in a calibrated manner, since the light is not …

Tires are an important vehicle component, as car handling, safety and fuel economy depend for a major part on the tire composition and construction. As a consequence, tires are improved continuously. The most prominent improvement in the recent past was the use of a silica-silane filler system in passenger …