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Mitochondrial dysfunction in human hypertrophic cardiomyopathy is linked to cardiomyocyte architecture disruption and corrected by improving NADH-driven mitochondrial respiration

Nollet, Edgar E; Duursma, Inez; Rozenbaum, Anastasiya; Eggelbusch, Moritz; Wüst, Rob C I; Schoonvelde, Stephan A C; Michels, Michelle; Jansen, Mark; van der Wel, Nicole N; Bedi, Kenneth C Jr; Margulies, Kenneth B; Nirschl, Jeff; Kuster, Diederik W D; van der Velden, Jolanda

Aims Genetic hypertrophic cardiomyopathy (HCM) is caused by mutations in sarcomere protein-encoding genes (i.e. genotype-positive HCM). In an increasing number of patients, HCM occurs in the absence of a mutation (i.e. genotype-negative HCM). Mitochondrial dysfunction is thought to be a key driver of …

2023-04-01AlgemeenArtikel

Blended Counseling And Protein Supplementation Increase Protein Intake In Community Dwelling Older Adults During A Resistance Exercise Program: Preliminary Results Of The Teams Rct

Benali, M. (Lectoraat Voeding En Beweging); van den Helder, J. (Lectoraat Voeding En Beweging); Schoufour, J. (Lectoraat Voeding En Beweging); Weijs, P. (Lectoraat Voeding En Beweging); Tieland, M. (Lectoraat Voeding En Beweging)

Rationale: In order to optimize training effects for prevention of sarcopenia and frailty in community dwelling older adults a higher daily protein intake is required. To increase total daily protein intake to optimal levels (minimal 1.2 g/kg/d, optimal 1.5 g/kg/d) during a resistance exercise training …

2023-04AlgemeenArtikel

Review of Presence, Induction and Isolation of Major Cellular Constituents From Porphyra Sensu Lato (Rhodophyceae), Including Mycosporine-Like Amino Acids (MAA’s)

van Groenigen, Jesse; Derksen, Goverdina; Timmermans, Klaas

Seaweeds from the genus Porphyra play a big economic role in seaweed aquaculture, mainly in Asia. In Europe, resources are put towards seaweed cultivation, but without attention to the Porphyra species which is also native to Europe. Different nomenclature and specifications are used to describe Porphyra, …

2023-03-26AlgemeenAndersoortig materiaal

Too low protein and energy intake in nursing homes residents

M Manders; A Nijhof; L Wijker; E Feskens; Elke Naumann; Marian de van der Schueren; Jos Borkent

2023AlgemeenArtikel

The impact of high versus standard enteral protein provision on functional recovery following intensive care admission (PRECISE trial)

van Gassel, Rob J. J.; Bels, Julia L. M.; Tartaglia, Katrien; van Bussel, Bas C. T.; van Kuijk, Sander M. J.; Deane, Adam M.; Puthucheary, Zudin; Weijs, Peter J. M. (Lectoraat Voeding En Beweging); Vloet, Lilian; Beishuizen, Bert; De Bie Dekker, Ashley; Fraipont, Vincent; Lamote, Stoffel; Ledoux, Didier; Scheeren, Clarissa; De Waele, Elisabeth; van Zanten, Arthur R. H.; Mesotten, Dieter; van de Poll, Marcel C. G.

Background Critically ill patients are subject to severe skeletal muscle wasting during intensive care unit (ICU) stay, resulting in impaired short- and long-term functional outcomes and health-related quality of life. Increased protein provision may improve functional outcomes in ICU patients by attenuating …

2023AlgemeenArtikel

Nocturnal Hemodialysis Leads to Improvement in Physical Performance in Comparison with Conventional Hemodialysis

Dam, Manouk; Weijs, Peter J. M. (Lectoraat Voeding En Beweging); van Ittersum, Frans J.; Hoekstra, Tiny; Douma, Caroline E.; van Jaarsveld, Brigit C.

End-stage kidney disease patients treated with conventional hemodialysis (CHD) are known to have impaired physical performance and protein-energy wasting (PEW). Nocturnal hemodialysis (NHD) was shown to improve clinical outcomes, but the evidence is limited on physical performance and PEW. We investigate …

2023AlgemeenArtikel

Postoperative muscle loss, protein intake, physical activity and outcome associations

Hogenbirk, Rianne N. M.; van der Plas, Willemijn Y.; Hentzen, Judith E. K. R.; van Wijk, Laura; Wijma, Allard G.; Buis, Carlijn I.; Viddeleer, Alain R.; de Bock, Geertruida H.; van der Schans, Cees P; van Dam, Gooitzen M.; Kruijff, Schelto; Klaase, Joost M.

Background: Skeletal muscle loss is often observed in intensive care patients. However, little is known about postoperative muscle loss, its associated risk factors, and its long-term consequences. The aim of this prospective observational study is to identify the incidence of and risk factors for surgery-related …

2022-11-17AlgemeenArtikel

GLIM-based malnutrition, protein intake and diet quality in preprocedural Transcatheter Aortic Valve Implantation (TAVI) patients

van Erck, D.; Tieland, M. (Lectoraat Voeding En Beweging); Adriaens, N. W.; Weijs, P. J. M. (Lectoraat Voeding En Beweging); Scholte Op Reimer, W.J.M.; Henriques, J.P.; Schoufour, J.D. (Lectoraat Voeding En Beweging)

BACKGROUND & AIMS: Diagnosed prevalence of malnutrition and dietary intake are currently unknown in patients with severe aortic stenosis planned to undergo Transcatheter Aortic Valve Implantation (TAVI). This study describes the preprocedural nutritional status, protein intake and diet quality. METHODS: …

2022-10AlgemeenArtikel

Early high protein provision and mortality in ICU patients including those receiving continuous renal replacement therapy

van Ruijven, Isabel M.; Stapel, Sandra N.; Girbes, Armand R. J.; Weijs, Peter J. M. (Lectoraat Voeding En Beweging)

BACKGROUND: Findings on the association between early high protein provision and mortality in ICU patients are inconsistent. The relation between early high protein provision and mortality in patients receiving CRRT remains unclear. The aim was to study the association between early high protein provision …

2022-09AlgemeenArtikel

Exploring future Dutch plant protein innovations

Sangster, B. (Student); Peeters, A. (Student); Ees, B. van (Student); Zuidberg, A.F.; Overgaag, J.

In opdracht van de Rabobank en het lectoraat Design Methoden in Food van HAS Hogeschool is er een20 weken durende bedrijfsopdracht uitgevoerd naar aanleiding van de verschuiving van dierlijke eiwitten naar plantaardige eiwitten, wat ook wel de eiwittransitie wordt genoemd. Het doel van dit onderzoek …

2022-07-01AlgemeenBachelor

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