Cardamonin is a natural chalcone that has been extensively investigated for its anticancer activity. However, its clinical relevance is still not explicit, limiting its progression into clinical trials and highlighting a persistent gap between preclinical evidence and practical application. This review …

Hyperhomocysteinemia is a risk factor for cardiovascular disease, neurological disorders, and bone abnormalities. The key enzyme in homocysteine metabolism, cystathionine-β-synthase (CBS) is recognized as a target for new homocysteine-lowering therapies including enzyme replacement and gene therapy. …

MNEXT (formerly the Center of Expertise – Biobased Economy (CoE BBE)) is researching about the link between Geopolymer, Alginate and Natural fibres treated using Alginate, more specifically about the potential usage of Sodium Alginate and Alginate-treated natural fibres as biological/sustainable binder/activator …

Clonal haematopoiesis of intermediate potential (CHIP) driven by somatic mutations in DNMT3A and TET2 has been recently recognized as a new risk factor for cardiovascular diseases (CVD). The haematopoietic clones with mutations in these genes are frequently found in myeloid malignancies and according …

Hands‐on simulations are increasingly used in vocational oriented curricula to create meaningful, occupation‐related learning experiences. However, more insight is required about precisely what characteristics in hands‐on simulations enhance outcomes that students need for their future occupation, such …

Een universeel en afneembaar boodschappenmandje voor aan een rolstoel is een product dat nog steeds op de markt ontbreekt. Hierdoor ondervinden rolstoelgebruikers veel ongemakken tijdens het zelfstandig doen van boodschappen. Dit project is bedoeld om dat gat in de markt op te vullen met een product …

Endothelial cells were isolated from arteries and veins obtained from elderly people at autopsy and propagated for 37 to 69 population doublings. The cells secreted tissue-type plasminogen activator (t-PA) and PA inhibitor-1, and, after subculturing, urokinase-type PA (u-PA) antigen. The following differences …

Plasma urokinase, a plasminogen activator immunochemically related to urinary urokinase (UK), was removed from human plasma (3.5 ng/ml) by immuno-depletion with antibodies raised against UK. The remaining plasminogen activator activity of the depleted plasma could not be inhibited by anti-UK antibodies …

An ELISA was set up using polyvinylchloride microtiter plates coated with rabbit anti-UK IgG's and affino-purified goat anti-UK IgG's as second antibody. Detection occurred with rabbit anti-goat IgG antibodies conjugated with alkaline phosphatase. The assay is specific for urokinase (UK) with a detection …