Objectives To assess the impact of BCG vaccination on systemic inflammation in neonates, focusing on sex-specific differences and the relationship between circulating inflammatory proteins and immune responses, including cytokine production and antibody levels. Methods A randomized clinical trial was …

Reinforcement learning offers a promising approach for personalized, early-stage detection of behavioral events such as agitation in individuals with dementia, particularly when contextual insights from care staff are integrated. Given the scarcity and the ethical constraints of real-world agitation …

Objective: Simulation training in medical settings is a cornerstone in medical education to practice technical and non-technical skills. The objective of this study was to evaluate user experiences and initial reactions to a multiplayer virtual reality (VR) simulation designed for anaesthesiologists. Methods: …

Background: Osteoarthritis (OA) is a chronic disease primarily affecting older adults, mainly impacting the hip and knee joints. The increasing prevalence of OA contributes to rising healthcare demands and costs. Current OA treatment guidelines emphasize the importance of self-management education and …

BACKGROUND: Preventing metabolic syndrome (MetS) and frailty in older adults is crucial for healthy aging. The association between MetS and physical frailty is well-documented, with low-grade inflammation as potential explanation. However, the association between MetS and frailty as a multidimensional …

The hip fracture causes significant disabilities in many elderly people. Many studies around the world have identified various risk factors for the hip fracture. The aim of this study was to systematically investigate the risk factors of hip fractures. This study is a systematic review of risk factors …

Blood flow restriction training voor de toename van kracht: een systematische literatuurstudie. Met samenvatting in het Engels. Includes a summary in English

Background: Chronic low-grade inflammatory profile (CLIP) is one of the pathways involved in type 2 diabetes (T2D). Currently, there is limited evidence for ameliorating effects of combined lifestyle interventions on CLIP in type 2 diabetes. We investigated whether a 13-week combined lifestyle intervention, …

Introduction: The optimal pre-participation screening strategy to identify athletes at risk for exercise-induced cardiovascular events is unknown. We therefore aimed to compare the American College of Sports Medicine (ACSM) and European Society of Cardiology (ESC) pre-participation screening strategies …

Objective: This study aims to assess the comparative effectiveness of a conventional splitting needle or a peelable cannula vs. the modified Seldinger technique (MST) by utilizing a dedicated micro-insertion kit across various clinically significant metrics, including insertion success, complications, …