Hyperhomocysteinemia is a risk factor for cardiovascular disease, neurological disorders, and bone abnormalities. The key enzyme in homocysteine metabolism, cystathionine-β-synthase (CBS) is recognized as a target for new homocysteine-lowering therapies including enzyme replacement and gene therapy. …

Drumul Taberei, a postwar modernist district of Bucharest, has a share in Romanian urban history with a start as a socialist high-rise utopia, subsequent densification in the ample green spaces under political repression and a downfall due to seismic threats. Through research the cultural and architectural …

Decarbonisation of urban logistics is a pressing issue. About one third of the freight-related CO2 emissions in the Netherlands relates to urban logistics, consisting of both vans and trucks. Although electrification is a feasible solution, delivery models that not only focus on reducing the carbon footprint, …

A replacement of cars with conventional internal combustion engines (ICEs) by electric vehicles (EVs) is seen by many as a means to improve local air quality, reduce dependence on fossil fuels and CO2 emissions. The market for EV is slowly developing with a growing number of (subsidized) manufacturers …

ABSTRACT Introduction: Somatic comorbidity is the main cause of reduced life expectancy in patients with substance use disorders (SUDs). Aim: This study aims to investigate somatic health challenges in patients with SUDs using the USS. Patient self-management of somatic health and quality of life were …

One of the most common materials to build infrastructure around the globe is Portland Cement Concrete, which is also one of the factors affecting economies nowadays. Portland Cement Concrete requires a large amount of raw materials in order to be produced, like milestone, which its extraction method …

Aims: To investigate the impact of consecutive perioperative care transitions on in-hospital recovery of patients who had primary total knee arthroplasty (TKA) over an 11-year period. Methods: This observational cohort study used electronic health record data from all patients undergoing preoperative …

This paper describes some explorations on the concept of disassemblability as an important circularity indicator for products because of its severe impact on reuse value. Although usefulness of the concept for determining disassembly strategies and for improving circular product design clearly shows …

Objective: To explore the nature and extent of possible residual complaints among Dutch hypothyroid patients using thyroid replacement therapy, we initiated a comprehensive study measuring health-related quality of life (QoL), daily functioning, and hypothyroidism-associated symptoms in patients and …

While the original definition of replacement focuses on the replacement of the use of animals in science, a more contemporary definition focuses on accelerating the development and use of predictive and robust models, based on the latest science and technologies, to address scientific questions without …