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Zocht je misschien: drugs, druk?

High diversity in SCCmec elements among multidrug-resistant Staphylococcus haemolyticus strains originating from paediatric patients; characterization of a new composite island

Farideh Hosseinkhani (Onderzoeker); Matthias Tammes Buirs (Student); Fereshteh Jabalameli (Onderzoeker); Mohammad Emaneini (Onderzoeker); Willem van Leeuwen (Lector)

Purpose. Staphylococcus haemolyticus has emerged as a highly antimicrobial-resistant healthcare-associated pathogen, in particular for patients admitted to neonatal intensive care. The objective of this study was to study the nature of SCCmec types among MDR-SH strains isolated from paediatric patients. Methodology. …

2018-07-01Natuur & LandbouwArtikel

High-quality genome sequence of the highly bacterium Staphylococcus haemolyticus, isolated from a neonatal bloodstream infection

Mohammad Emaneini (Onderzoeker); Farideh Hosseinkhani (Onderzoeker); Willem van Leeuwen (Lector)

Using Illumina HiSeq and PacBio technologies, we sequenced the genome of the multidrug-resistant bacterium Staphylococcus haemolyticus, originating from a bloodstream infection in a neonate. The sequence data can be used as an accurate reference sequence.

2017-07-20Natuur & LandbouwArtikel

Monoterpene isolated from the essential oil of Trachyspermum ammi is cytotoxic to multidrug-resistant Pseudomonas aeruginosa and Staphylococcus aureus strains

Fereshteh Jabalameli (Onderzoeker); Farideh Hosseinkhani (Onderzoeker); Maryam Banar (Onderzoeker); Nafiseh Abdellahi (Onderzoeker); Morovat Taherikalani (Onderzoeker); Willem van Leeuwen (Lector); Mohammad Emaneini (Onderzoeker)

INTRODUCTION: The aim of this study was to determine whether an herbal extract containing monoterpene exhibited activity against multidrug-resistant Staphylococcus aureus and Pseudomonas aeruginosa isolated from clinical infection samples. METHODS: The essential oil of Trachyspermum ammi (L.) Sprague …

2016Natuur & LandbouwArtikel

Antibiotic use in children with acute respiratory or ear infections

Harald J. Hamre (Onderzoeker); Anja Glockmann (Onderzoeker); Reinhard Schwarz (Onderzoeker); David S. Riley (Onderzoeker); Erik Baars (Lector); Helmut Kiene (Onderzoeker); Gunver S. Kienle (Onderzoeker)

Children with acute respiratory or ear infections (RTI/OM) are often unnecessarily prescribed antibiotics. Antibiotic resistance is a major public health problem and antibiotic prescription for RTI/OM should be reduced. Anthroposophic treatment of RTI/OM includes anthroposophic medications, nonmedication …

2014-11-18GezondheidArtikel

Prednisolone induces the Wnt signalling pathway in 3T3-L1 adipocytes

Fleuren, Wilco W M; Linssen, Margot M L; Toonen, Erik J M; van der Zon, Gerard C M; Guigas, Bruno; de Vlieg, Jacob; Dokter, Wim H A; Ouwens, D Margriet; Alkema, Wynand

Synthetic glucocorticoids are potent anti-inflammatory drugs but show dose-dependent metabolic side effects such as the development of insulin resistance and obesity. The precise mechanisms involved in these glucocorticoid-induced side effects, and especially the participation of adipose tissue in this …

2013-03-19AlgemeenArtikel

Org 214007-0

van Lierop, Marie-José C; Alkema, Wynand; Laskewitz, Anke J; Dijkema, Rein; van der Maaden, Hans M; Smit, Martin J; Plate, Ralf; Conti, Paolo G M; Jans, Christan G J M; Timmers, C Marco; van Boeckel, Constant A A; Lusher, Scott J; McGuire, Ross; van Schaik, Rene C; de Vlieg, Jacob; Smeets, Ruben L; Hofstra, Claudia L; Boots, Annemieke M H; van Duin, Marcel; Ingelse, Benno A; Schoonen, Willem G E J; Grefhorst, Aldo; van Dijk, Theo H; Kuipers, Folkert; Dokter, Wim H A

Glucocorticoids (GCs) such as prednisolone are potent immunosuppressive drugs but suffer from severe adverse effects, including the induction of insulin resistance. Therefore, development of so-called Selective Glucocorticoid Receptor Modulators (SGRM) is highly desirable. Here we describe a non-steroidal …

2012-11-12AlgemeenArtikel

Drug-induced caspase 8 upregulation sensitises cisplatin-resistant ovarian carcinoma cells to rhTRAIL-induced apoptosis

Duiker, E.; van der Heij-Meijer, Annemieke; van der Bilt, A. R. M.; Meersma, G.J.; Kooi, N.; van der Zee, A.G.J.; de Vries, E.G.E.; de Jong, Steven

Background: Drug resistance is a major problem in ovarian cancer. Triggering apoptosis using death ligands such as tumour necrosis factor-related apoptosis inducing ligand (TRAIL) might overcome chemoresistance. Methods: We investigated whether acquired cisplatin resistance affects sensitivity to recombinant …

2011-04-01AlgemeenArtikel

Investigating the potential and feasibility of conducting scientific research on the impact of phytonics 'gluco balance' on insulin resistant horses

Denkhaus, L. (Student); Laarakker, E.; Verweij, F.

Het bedrijf Phytonics heeft het natuurlijke gezondheidsproduct, ‘‘Gluco balance’’ ontwikkeld, dat paarden met symptomen van insulineresistentie ondersteunt. Voor dit product wordt geclaimd, dat het de gevoeligheid van de insuline cel receptoren verbetert, en dat hiermee de insuline- en glucoseconcentraties …

2011Natuur & LandbouwBachelor

Playing the DISC: turning on TRAIL death receptor-mediated apoptosis in cancer

Pennarun, Bodvaël; van der Heij-Meijer, Annemieke; de Vries, Elisabeth G.E.; Kleibeuker, Jan H.; Kruyt, Frank; de Jong, Steven

Formation of the pro-apoptotic death-inducing signaling complex (DISC) can be initiated in cancer cells via binding of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) to its two pro-apoptotic receptors, TRAIL receptor 1 (TRAIL-R1) and TRAIL-R2. Primary components of the DISC are trimerized …

2010-04-01AlgemeenAndersoortig materiaal

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