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The influence of ROS1 fusion partners and resistance mechanisms in ROS1-TKI-treated non-small cell lung cancer patients

Zwierenga, Fenneke; Dijkhuizen, Christa (Biomolecules & Health); Korthuis, Patrick; Timens, Wim; Groen, Harry; Hiltermann, Jeroen; van den Berg, Anke; Drayer, Lyndsay; van der Wekken, Anthonie

Clinical outcomes in ROS1-fusion positive (ROS1+) non-small cell lung cancer (NSCLC) by fusion partner and resistance mechanisms are limited. This cohort study included 56 ROS1+ patients (FISH or NGS confirmed); fusion partners were identified in 27 cases, including CD74 (n = 10), EZR (n = 7), and SDC4 …

2025-08-29GezondheidArtikel

Infectieziekten (en vaccines)

Milder, Fin

Gastcollege.

2025-06-23AlgemeenConferentiebijdrage

ROS1+ in vitro models

Dijkhuizen, Christa (Biomolecules & Health); Korthuis, Patrick; Aguado, Cristina; Garcia-Román, Silvia; Aguilar-Hernández, Andrés; Drayer, Lyndsay; Hiltermann, Jeroen; De Looff, Margot (Biomolecules & Health); Milder, Fin (Biomolecules & Health); van den Berg, Anke; van der Wekken, Anthonie

2025-06-17GezondheidConferentiebijdrage

Assessment of two new ROS1+ NSCLC patient-derived cell lines as in vitro models for TKI resistance studies

Dijkhuizen, Christa (Biomolecules & Health); Korthuis, Patrick; Aguado, Cristina; Garcia-Román, Silvia; Aguilar-Hernández, Andrés; Drayer, Lyndsay; De Looff, Margot (Biomolecules & Health); Milder, Fin (Biomolecules & Health); van der Wekken, Anthonie; van den Berg, Anke

2025-06-13GezondheidConferentiebijdrage

Lectorate Biomolecules & Health

Milder, Fin

2025-04-17AlgemeenConferentiebijdrage

Onderzoeksmiddag Instituut Life Science & Technology

Milder, Fin

2025-04-17AlgemeenConferentiebijdrage

Het complementsysteem

Milder, Fin

2025-01-08AlgemeenConferentiebijdrage

Melt Electrowriting of Polyhydroxyalkanoates for Enzymatically Degradable Scaffolds

Gładysz, Magdalena Z.; Ubels, Didi; Koch, Marcus; Amirsadeghi, Armin; Alleblas, Frederique; Kamperman, Marleen; Siebring, Jeroen; Nagelkerke, Anika; Włodarczyk-Biegun, Małgorzata K.; van Vliet, Sander

Melt electrowriting (MEW) enables precise scaffold fabrication for biomedical applications. With a limited number of processable materials with short and tunable degradation times, polyhydroxyalkanoates (PHAs) present an interesting option. Here, poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) and …

2024-11-12AlgemeenArtikel

L2026M+G2032R variant confers resistance to ROS1 tyrosine kinase inhibitors in SCL34A2-ROS1 overexpressing Ba/F3 cells through a reduced ATP binding pocket volume

Dijkhuizen, Christa (Biomolecules & Health); Korthuis, Patrick; Vilachã, Juliana F.; Smelt, Maaike; van der Wekken, Anthonie; van den Berg, Anke; Drayer, Lyndsay

Background The ROS1 G2032R mutation is the most common on-target resistance mutation in crizotinib treated ROS1-positive lung cancer patients. The aim of our study was to investigate resistance mechanisms in SCL34A2-ROS1G2032R positive Ba/F3 cells against second line treatment with lorlatinib. Methods …

2023-10-21GezondheidConferentiebijdrage

SLC34A2-ROS1 L2026M+G2032R confers resistance to ROS1 tyrosine kinase inhibitors in Ba/F3 cells through a reduced ATP binding pocket volume

Dijkhuizen, Christa (Biomolecules & Health); Korthuis, Patrick; Vilachã, Juliana F.; Smelt, Maaike; van der Wekken, Anthonie; van den Berg, Anke; Drayer, Lyndsay

2023GezondheidConferentiebijdrage

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