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We tested the hypothesis that in human ageing a decreased intramuscular acylcarnitine status is associated with (pre-)frailty, reduced physical performance and altered mitochondrial function. Results showed that intramuscular total carnitine levels and acetylcarnitine levels were lower in (pre-)frail old females compared to fit old females and young females, whereas no differences were observed in males. The low intramuscular acetylcarnitine levels in females correlated with low physical performance, even after correction for muscle mass (%), and were accompanied with lowered expression of genes involved in mitochondrial energy production and functionality. We concluded that in (pre-)frail old females, intramuscular total carnitine levels and acetylcarnitine levels are decreased, and this decrease is associated with reduced physical performance and low expression of a wide range of genes critical for mitochondrial function. The results stress the importance of taking sex differences into account in ageing research.

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OrganisatieHogeschool Inholland
OpleidingFood Commerce and Technology
AfdelingDomein Agri, Food & Life Sciences
LectoraatHealth and Food
Gepubliceerd inThe FASEB Journal. Wiley Periodicals LLC on behalf of Federation of American Societies for Experimental Biology, New York, Vol. 34, Pagina's: 11658-11671
Datum2020-06-15
TypeArtikel
DOI10.1096/fj.202000493R
TaalEngels

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