HBO Kennisbank

6 Resultaten

Sorteer op:

Besluitvorming rondom de Non Alcoholische Fatty Liver Disease (NAFLD) en Non-Alcoholische Steatose Hepatitis (NASH) patiënt met fibrosegraad F0-F1, wel of niet terugverwijzen naar de eerstelijnszorg?

Hulsegge, AJ (Anja) (Student)

Probleemstelling: NAFLD/NASH is een aandoening welk samen gaat met aanwezigheid van diabetes mellitus (DMII),verhoogd alat-waarde, hyperlipidemie en cardiovasculaire aandoeningen. De fibroscan® is een gevalideerd instrument welk de mate van leverfibrose vaststelt. Aantal NASH/NAFLD patiënten in tweedelijnszorg …

2017-09-01GezondheidMaster

Prednisolone induces the Wnt signalling pathway in 3T3-L1 adipocytes

Fleuren, Wilco W M; Linssen, Margot M L; Toonen, Erik J M; van der Zon, Gerard C M; Guigas, Bruno; de Vlieg, Jacob; Dokter, Wim H A; Ouwens, D Margriet; Alkema, Wynand

Synthetic glucocorticoids are potent anti-inflammatory drugs but show dose-dependent metabolic side effects such as the development of insulin resistance and obesity. The precise mechanisms involved in these glucocorticoid-induced side effects, and especially the participation of adipose tissue in this …

2013-03-19AlgemeenArtikel

Identification of new biomarker candidates for glucocorticoid induced insulin resistance using literature mining

Fleuren, Wilco WM; Toonen, Erik JM; Verhoeven, Stefan; Frijters, Raoul; Hulsen, Tim; Rullmann, Ton; van Schaik, René; de Vlieg, Jacob; Alkema, Wynand

Background: Glucocorticoids are potent anti-inflammatory agents used for the treatment of diseases such as rheumatoid arthritis, asthma, inflammatory bowel disease and psoriasis. Unfortunately, usage is limited because of metabolic side-effects, e.g. insulin resistance, glucose intolerance and diabetes. …

2013-02-04AlgemeenArtikel

Org 214007-0

van Lierop, Marie-José C; Alkema, Wynand; Laskewitz, Anke J; Dijkema, Rein; van der Maaden, Hans M; Smit, Martin J; Plate, Ralf; Conti, Paolo G M; Jans, Christan G J M; Timmers, C Marco; van Boeckel, Constant A A; Lusher, Scott J; McGuire, Ross; van Schaik, Rene C; de Vlieg, Jacob; Smeets, Ruben L; Hofstra, Claudia L; Boots, Annemieke M H; van Duin, Marcel; Ingelse, Benno A; Schoonen, Willem G E J; Grefhorst, Aldo; van Dijk, Theo H; Kuipers, Folkert; Dokter, Wim H A

Glucocorticoids (GCs) such as prednisolone are potent immunosuppressive drugs but suffer from severe adverse effects, including the induction of insulin resistance. Therefore, development of so-called Selective Glucocorticoid Receptor Modulators (SGRM) is highly desirable. Here we describe a non-steroidal …

2012-11-12AlgemeenArtikel

ss-TEA

umc, radboud; Fleuren, Wilco W M; Verhoeven, Stefan; van den Beld, Sven; Alkema, Wynand; de Vlieg, Jacob; Klomp, Jan P G

Background: G-protein coupled receptors (GPCRs) are involved in many different physiological processes and their function can be modulated by small molecules which bind in the transmembrane (TM) domain. Because of their structural and sequence conservation, the TM domains are often used in bioinformatics …

2011-08-10AlgemeenArtikel

Identification of two types of protein immunochemically related to urinary urokinase occurring in human plasma

Binnema, D J; Dooijewaard, G; van Iersel, J J

Plasma urokinase, a plasminogen activator immunochemically related to urinary urokinase (UK), was removed from human plasma (3.5 ng/ml) by immuno-depletion with antibodies raised against UK. The remaining plasminogen activator activity of the depleted plasma could not be inhibited by anti-UK antibodies …

1987-01-15AlgemeenArtikel

Vorige Volgende