Over time memories are believed to undergo a time-dependent reorganization in the brain through a process known as systems consolidation during which they become less dependent on the hippocampus and more dependent on the neocortical structures. This reorganization is accompanied by a generalization …

Alzheimer's disease (AD) is the common neurodegenerative disorder and the most frequent cause of dementia. The disease accounts around 80% of all dementia diagnoses. The main reason of developing AD is amyloid cascade which starts from missense mutations in APP (amyloid precursor protein), Rho-associated …

Clonal haematopoiesis of intermediate potential (CHIP) driven by somatic mutations in DNMT3A and TET2 has been recently recognized as a new risk factor for cardiovascular diseases (CVD). The haematopoietic clones with mutations in these genes are frequently found in myeloid malignancies and according …

Cardiovascular diseases (CVDs) are by far the leading cause of death due to non communicable diseases in the world. The development of CVDs in many cases is caused by atherosclerosis. In atherosclerosis, plaques in blood vessels are formed by the excessive accumulation of lipids in the endothelial lining. …

5% to 10% of all cancers are linked to gene mutations inherited from parents. The most common gene related to hereditary cancer is the p53 gene. It is a crucial tumor suppressor. However, the mutated gene is commonly inherited from one generation to another one. The functions of p53 resume to the activation …

Diabetes remains a major risk for atherosclerotic-cardiovascular disease (CVD). While many mechanisms have been explored, the full extent of how diabetes promotes CVD remains unknown. An emerging area in diabetes is the influence of epigenetic regulation of gene expression. Diabetes has been shown to …